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April 1983, Vol 137, No. 4 >
Article | April 1983

Acetaminophen Poisoning in Infancy FREE

John W. Greene, MD; Lisa Craft, MD; Fayez Ghishan, MD
[+] Author Affiliations

Reprint requests to Department of Pediatrics, Vanderbilt Medical Center, Nashville, TN 37232 (Dr Greene).


Am J Dis Child. 1983;137(4):386-387. doi:10.1001/archpedi.1983.02140300064018.
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References
Comments

• Acetaminophen is widely used in children of all ages, and overdosage from this medication is common. Although severe hepatotoxicity from overdosage occurs in adults, acetaminophen seems to have a wide margin of safety in younger children. This has been ascribed to altered pharmacokinetics in this age group. We report two cases in which severe acetaminopheninduced hepatotoxicity occurred in two infants. Neither infant reportedly received potentially toxic dosages, by history, but toxic drug levels were present in both.

(Am J Dis Child 1983;137:386-387)

REFERENCES

1 +
American Academy of Pediatrics Committee on Drugs:  Commentary on acetaminophen . Pediatrics 1978;;61:1-5.
2 +
Peterson RG, Rumack RH:  Pharmacokinetics of acetaminophen in children . Pediatrics 1978;;62( (suppl) ):877-879.
3 +
Piperno E, Mosher AH, Berssenbruegge DA, et al:  Pathophysiology of acetaminophen overdosage toxicity: Implications for management . Pediatrics 1978;;62( (suppl) ):880-889.
4 +
Rumack RH, Peterson RG:  Acetaminophen overdosage: Incidence, diagnosis, and management in 416 patients . Pediatrics 1978;;62( (suppl) ): 898-903.
5 +
Lovejoy FH Jr:  Aspirin and acetaminophen: A comparative view of their antipyretic and analgesic activity . Pediatrics 1978;;62( (suppl) ):904-909.
6 +
Rumack RH:  Aspirin versus acetaminophen: A comparative view . Pediatrics 1978;; 62( (suppl) ):943-946.
7 +
Alam SN, Roberts RJ, Fischer LJ:  Age-related differences in salicylamide and acetaminophen conjugation in man . J Pediatr 1977;;90: 130-135.
8 +
Sutton E, Soyka LF:  How safe is acetaminophen? Clin Pediatr 1973;;12:692-696.
9 +
Barker JD Jr, DeCarle DJ, Anuras S:  Chronic excessive acetaminophen use and liver damage . Ann Intern Med 1977;;87:299-301.
10 +
Mitchell JR, Thorgursson SS, Potter WZ, et al:  Acetaminophen-induced hepatic injury: Protective role of glutathione and rationale for therapy . Clin Pharmacol Ther 1974;;16:676-684.
11 +
Rollins ED, Bahr CV, Glaumann H, et al:  Acetaminophen: Potentially toxic metabolite formed by human fetal and adult liver microsomes and isolated fetal liver cells . Science 1979;; 205:1414-1416.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
American Academy of Pediatrics Committee on Drugs:  Commentary on acetaminophen . Pediatrics 1978;;61:1-5.
2 +
Peterson RG, Rumack RH:  Pharmacokinetics of acetaminophen in children . Pediatrics 1978;;62( (suppl) ):877-879.
3 +
Piperno E, Mosher AH, Berssenbruegge DA, et al:  Pathophysiology of acetaminophen overdosage toxicity: Implications for management . Pediatrics 1978;;62( (suppl) ):880-889.
4 +
Rumack RH, Peterson RG:  Acetaminophen overdosage: Incidence, diagnosis, and management in 416 patients . Pediatrics 1978;;62( (suppl) ): 898-903.
5 +
Lovejoy FH Jr:  Aspirin and acetaminophen: A comparative view of their antipyretic and analgesic activity . Pediatrics 1978;;62( (suppl) ):904-909.
6 +
Rumack RH:  Aspirin versus acetaminophen: A comparative view . Pediatrics 1978;; 62( (suppl) ):943-946.
7 +
Alam SN, Roberts RJ, Fischer LJ:  Age-related differences in salicylamide and acetaminophen conjugation in man . J Pediatr 1977;;90: 130-135.
8 +
Sutton E, Soyka LF:  How safe is acetaminophen? Clin Pediatr 1973;;12:692-696.
9 +
Barker JD Jr, DeCarle DJ, Anuras S:  Chronic excessive acetaminophen use and liver damage . Ann Intern Med 1977;;87:299-301.
10 +
Mitchell JR, Thorgursson SS, Potter WZ, et al:  Acetaminophen-induced hepatic injury: Protective role of glutathione and rationale for therapy . Clin Pharmacol Ther 1974;;16:676-684.
11 +
Rollins ED, Bahr CV, Glaumann H, et al:  Acetaminophen: Potentially toxic metabolite formed by human fetal and adult liver microsomes and isolated fetal liver cells . Science 1979;; 205:1414-1416.

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