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Evidence of Non-A, Non-B Hepatitis in Children With Acute Leukemia and Chronic Liver Disease

Anna Locasciulli, MD; Alfredo Alberti, MD; Roberto Barbieri, MD; Giuseppe Realdi, MD; Cornelio Uderzo, MD; Bernard Portmann, MRCPath; Giuseppe Masera, MD
Am J Dis Child. 1983;137(4):354-356. doi:10.1001/archpedi.1983.02140300036010.
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• Eleven children with acute lymphoblastic leukemia and chronic liver disease, who had negative reactions for hepatitis B virus markers in the liver, were studied at the time of therapy withdrawal for an antigen-antibody system linked to non-A, non-B (NANB) hepatitis infection. By immunofluorescence, six of the 11 children had a positive reaction for the NANB antigen in the liver, and five of these six children also had a positive reaction for the NANB antibody in serum. Histologic lesions were more severe in patients with the NANB antigen in the liver compared with those with a negative reaction.

(Am J Dis Child 1983;137:354-356)


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