0
Article |

Encephalopathy With Metronidazole in a Child

JULIAN BAILES, MD; JOHN WILLIS, MD; CEDRIC PRIEBE, MD; RICHARD STRUB, MD
Am J Dis Child. 1983;137(3):290-291. doi:10.1001/archpedi.1983.02140290076021.
Text Size: A A A
Published online

Recent reports imply that high doses of metronidazole hydrochloride cause CNS toxic effects in adults.1,2 To our knowledge, such toxic effects have not been reported in children. We describe a child who experienced seizures and prolonged neurologic abnormalities after the administration of intravenous (IV) metronidazole.

Report of a Case.—A previously well 12-year-old boy had surgery for a perforated appendix and generalized peritonitis on June 9, 1981. Postoperatively, therapy with IV tobramycin sulfate, 50 mg every eight hours, and clindamycin phosphate, 175 mg every six hours, was started; chloramphenicol sodium succinate, 600 mg every six hours, was added on June 11 because of persistent fever and abdominal tenderness. Tobramycin and chloramphenicol therapy was stopped on June 14, when the initial peritoneal culture showed Escherichia coli resistant to those drugs. Intravenous gentamicin sulfate, 70 mg every eight hours, and cefamandole nafate, 1 g every eight hours, were then added to the

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();