Nephrotic Syndrome and Diffuse Mesangial Proliferative Glomerulonephritis in Children FREE

Eduardo H. Garin, MD; William H. Donnelly, MD; Dennis Geary, MB, BCh, BAO; George A. Richard, MD

Reprint requests to Department of Pediatrics, Box J-296, J. Hillis Miller Health Center, University of Florida College of Medicine, Gainesville, FL 32610 (Dr Garin).

Am J Dis Child. 1983;137(2):109-113. doi:10.1001/archpedi.1983.02140280007003.

Text Size: A A A

Published online

Article

References

Comments

ABSTRACT

ABSTRACT | REFERENCES

• The clinical course, response to therapy, and outcome were analyzed in 25 children with nephrotic syndrome associated with moderate to severe mesangial cell proliferation. The conditions of more than two thirds of the patients (16/23) failed to respond to prednisone therapy, and renal insufficiency or failure developed in 13. Our data suggest an association between response to therapy and degree of mesangial cell proliferation. Persistent nephrotic syndrome was associated with slow deterioration of renal function.

(Am J Dis Child 1983;137:109-113)

REFERENCES

ABSTRACT | REFERENCES

International Study of Kidney Disease in Children: The nephrotic syndrome in children: Prediction of histopathology from clinical and laboratory characteristics at time of diagnosis . Kidney Int 1978;;13:159-165.

Waldherr R, Gubler MC, Levy M, et al: The significance of pure diffuse mesangial proliferation in idiopathic nephrotic syndrome . Clin Nephrol 1978;;10:171-179.

White RHR, Glasgow EF, Mills RJ: Clinicopathological study of nephrotic syndrome in childhood . Lancet 1970;;1:1353-1359.

Brown EA, Upadhyaya K, Hayslett JP, et al: The clinical course of mesangial proliferative glomerulonephritis . Medicine 1979;;58:295-303.

White RHR: Mesangial proliferative glomerulonephritis in childhood , in Kincaid-Smith P, Mathew TH, Becker EL (eds): Glomerulonephritis . New York, John Wiley & Sons Inc, 1973;, pp 383-391.

Murphy WM, Jukkola AF, Roy S III: Nephrotic syndrome with mesangial-cell proliferation in children: A distinct entity? Am J Clin Pathol 1979;;72:42-47.

International Study of Kidney Disease in Children: Primary nephrotic syndrome in children: Clinical significance of histopathologic variants of minimal change and of diffuse mesangial hypercellularity . Kidney Int 1981;;20:765-771.

Report of Task Force on Blood Pressure Control in Children . Pediatrics 1977;;59( (suppl) ): 797-820.

Greifer I, Barnett HL: International workshop on risk/benefit assessment of cyclophosphamide in renal disease . Kidney Int 1972;;2:352-353.

McCrory WW, Shibuya M, Lu WH, et al: Therapeutic and toxic effects observed with different dosage programs of cyclophosphamide in treatment of steroid-responsive but frequently relapsing nephrotic syndrome . J Pediatr 1973;; 82:614-618.

Cutler JS, Ederer F: Maximum utilization of the life table method in analyzing survival . J Chronic Dis 1958;;8:699-712.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal