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γ-Glutamyl Transpeptidase and Infantile Biliary Obstruction

Am J Dis Child. 1982;136(8):755. doi:10.1001/archpedi.1982.03970440099037.
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Sir.—We read with interest the article by Wright and Christie (Journal 1981;135:134-136) on the potential usefulness of serum γ-glutamyl trans-peptidase (GGTP) levels for the diagnosis of biliary atresia. We would like to describe our experience in this regard.

Twenty infants aged 3 through 12 weeks were admitted with cholestatic jaundice during a six-year period. Serum GGTP levels were determined in all. On laparotomy seven patients proved to have extrahepatic biliary atresia and one intrahepatic biliary atresia with patent extrahepatic ducts. Six had neonatal hepatitis; three underwent diagnostic laparotomy and in three the jaundice spontaneously cleared. Six had α1-antitrypsin deficiency with serum levels ranging from 65 to 130 mg/dL; four had protease inhibitor ZZ and two had

Diagnostic Data From 20 Infants With Suspected Biliary Atresia

Case/Sex/Age at Diagnosis, wk GGTP, IU/L SGOT, IU/L SGPT, IU/L Serum Bilirubin, Direct/Total, mg/dL Rose Bengal α1-A, Sodium I 131


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