In Reply.—The experience of Dr Lindemann is certainly a gratifying validation of our laboratory research and our clinical experiences at The Medical College of Pennsylvania, Philadelphia. Dr Lindemann's observation of endotracheal administration of epinephrine in neonates further demonstrates the usefulness of this route for emergency administration of drugs. As Dr Lindemann noted, this procedure can be invaluable not only in neonates, but in older children and adults as well. It is important to note that several other emergency drugs are efficacious when administered endotracheally.
Our most recent experience involved the use of endotracheally administered atropine sulfate.1 We could obtain normal BP and pulse rate within two minutes of administering 1.0 mg of atropine sulfate endotracheally in a patient with bradycardiac cardiovascular collapse. Following our report of successful reversal of morphine-induced respiratory depression in rabbits by the use of endotracheally administered naloxone,2 colleagues at the University of New