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Disseminated Aspergillosis

Am J Dis Child. 1982;136(7):654. doi:10.1001/archpedi.1982.03970430086035.
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Sir.—It is well known that disseminated aspergillosis in immunocompromised patients is a fatal disease. In children affected by chronic granulomatous disease (CGD), therapy with amphotericin B alone is only marginally effective, and granulocyte transfusions or a surgical approach are often required.

Corrado et al1 suggested the combined use of rifampin and amphotericin B to treat a child with CGD and aspergillosis.

We report a new case of systemic infection caused by Aspergillus fumigatus in a boy suffering from CGD in whom successful treatment has been obtained with the combination of amphotericin B and rifampin.

Report of a Case.—A 14-year-old boy who had CGD2 was admitted to the Division of Infectious Diseases, University of Milan, Italy, because he was febrile (39.5 °C) and had right-sided pneumonia with pleural effusion and two fluctuant masses over the lateral aspect of the chest wall on the right side. The diagnosis


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