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Familial Complete Precocious Puberty Affecting Both Sexes

S. DOUGLAS FRASIER, MD; PAUL F. BRENNER, MD
Am J Dis Child. 1982;136(6):560-561. doi:10.1001/archpedi.1982.03970420084027.
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Sir.—In their article "Familial Precocious Puberty in a Brother and Sister" (Journal 1981;135:78-79), Hopwood et al described a family in which precocious puberty occurred in both sexes. To our knowledge, only one other similar family has been described.1 We have observed a third family (Figure) in which complete precocious puberty developed in three siblings, one girl and two boys.

Report of Cases.Case 1.—A girl (Figure, patient II-1) was first seen at the age of 5 years 5 months for evaluation of breast development and rapid growth. Pubic and axillary hair had not appeared. There was no history to suggest CNS disease.

The patient's height was 124 cm (height age, 7 years 9 months), and her weight was 31 kg (weight age, 9½ years). There was 8 cm of breast tissue bilaterally. The clitoris was normal, and the labia majora and minora were prepubertal. Vaginoscopy showed a

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