We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Ambiguous Genitalia in a Term Female Infant due to Exposure to Danazol in Utero

Am J Dis Child. 1982;136(5):474. doi:10.1001/archpedi.1982.03970410092029.
Text Size: A A A
Published online


Sir.—In the article, "Transient Adrenogenital Syndrome due to Exposure to Danazol in Utero" (Journal 1981;135:1032-1034), Castro-Magana et al described a 980-g infant delivered at 27 weeks' gestation with ambiguous genitalia. The mother had received danazol for endometriosis through the 20th week of pregnancy. This infant had a low serum cortisol level and elevated 11-deoxycortisol, 17α-hydroxyprogesterone, adrenocorticotropic hormone, androstenedione, and testosterone levels.

We also saw a 12-hour-old, 2.4-kg, term female infant with ambiguous genitalia whose mother had endometriosis and was receiving danazol for the first four months of her pregnancy. The infant had a phallus that measured 0.75 cm and complete posterior labial fusion. There were no scrotal masses, and a rectal examination revealed a small infantile uterus. The karyotype was 46,XX. The urine 17-ketosteroid level was 0.5 mg/24 hr. Serum electrolyte determinations were normal. The 17α-hydroxyprogesterone level was 145 ng/dL, which is

Clarence H. White Family Group (Maynard and


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.