The prevalence of systemic candidal or fungal infections has steadily increased during the era of antibiotic therapy.1-4 Particularly susceptible are patients with lymphoreticular malignancies and organ transplant recipients receiving immunosuppressive therapy and frequent courses of broad-spectrum antibiotics. The incidence of fungal infections in these patients is as high as 10% to 20%,5,6 and the case fatality rate is as high as 28% to 33%.2
Although candidal involvement of almost every organ system has been reported,1-3,7 fungal cholecystitis has rarely been noted. The purpose of this article is to describe a leukemic child with Candida albicans involvement of the gallbladder as the primary manifestation of systemic candidiasis.
Report of a Case.—A 12-year-old boy was admitted to Children's Memorial Hospital, Chicago, with a one-week history of fever, cough, and lethargy. He was pale and cachetic, with generalized lymphadenopathy. The liver edge was palpable 3 cm below the