0
May 1982, Vol 136, No. 5 >
Article | May 1982

Use of Medium-Chain Triglycerides in Feeding the Low-Birth-Weight Infant FREE

Emi Okamoto, MD; Catherine R. Muttart, RN, MS; Christine L. Zucker, MS; William C. Heird, MD
[+] Author Affiliations

Reprints not available.


Am J Dis Child. 1982;136(5):428-431. doi:10.1001/archpedi.1982.03970410046011.
Text Size: A A A
Published online
Article
References
Comments

• Intestinal fat absorption and anthropometric and clinical variables were monitored weekly in 21 low-birth-weight (LBW) infants fed either a whey-predominant cow's-milk formula (formula 1) or identical formulas with medium-chain triglycerides (MCTs) comprising 40% (formula 2) or 80% (formula 3) of the fat content. Fat absorption of infants fed formula 1 averaged 86.7% of intake, whereas that of infants fed formulas 2 and 3 averaged 93.8% and 95.4%, respectively. However, no differences in weight, length, head circumference, or skin fold thickness were observed. Moreover, intestinal symptoms were encountered more frequently in infants fed formulas 2 and 3. This demonstrated failure of the resulting small increase in fat absorption incident to MCTs either to promote enhanced growth or to confer obvious clinical benefit does not support the increasing use of MCT formulas for routine feeding of LBW infants.

(Am J Dis Child 1982;136:428-431)

REFERENCES

1 +
Yamashita F, Shibuya S, Funatsu I, et al:  Absorption of medium-chain triglyceride in the low birth weight infant and evaluation of MCT milk formula for low birth weight infant nutrition using the Latin square technique . Kurume Med J 1969;;16:191-201.
2 +
Andrews BF, Lorch V:  Improved fat and calcium absorption in LBW infants fed a medium-chain triglyceride containing formula , abstracted. Pediatr Res 1974;;8:104.
3 +
Roy CC, Ste-Marie M, Chartrand L, et al:  Correction of the malabsorption of the preterm infants with a medium-chain triglyceride formula . J Pediatr 1975;;86:446-450.
4 +
Tantibhendyangkul P, Hashim SA:  Medium-chain triglyceride feeding in premature infants: Effects on fat and nitrogen absorption . Pediatrics 1975;;55:359-370.
5 +
Tantibhendyangkul P, Hashim SA:  Medium-chain triglyceride feeding in premature infants: Effects on calcium and magnesium absorption . Pediatrics 1978;;61:537-545.
6 +
Shenai PJ, Reynolds JW, Babson SG:  Nutritional balance studies in very-low-birth-weight infants: Enhanced nutrient retention rates by an experimental formula . Pediatrics 1980;;66:233-238.
7 +
Dubowitz LM, Dubowitz V, Goldberg C:  Clinical assessment of gestational age in the newborn infant . J Pediatr 1970;;77:1-10.
8 +
Jeejeebhoy KN, Ahmad S, Kozak G:  Determination of fecal fats containing both medium and long chain triglycerides and fatty acids . Clin Biochem 1970;;3:157-163.
9 +
Hansen JL, Freier EF:  The measurement of serum magnesium by atomic absorption spectrophotometry . Am J Tech 1967;;33:158-166.
10 +
Trudeau DL, Freier EF:  Determination of calcium in urine and serum by atomic absorption spectrophotometry . Clin Chem 1967;;13:101-114.
11 +
Snedecor GW, Cochran WG: Statistical Methods . Ames, Iowa, Iowa State University Press, 1967;, pp 258-298.
12 +
Watkins JB, Szczepanik P, Gould JB, et al:  Bile salt metabolism in the human premature infant . Gastroenterology 1975;;69:706-713.
13 +
Zoppi G, Andreotti G, Pajno-Ferrara F, et al:  Exocrine pancreas function in premature and full term neonates . Pediatr Res 1972;;6:880-886.
14 +
Greenberger NJ, Skillman TG:  Medium-chain triglycerides . N Engl J Med 1968;;280:1045-1058.
15 +
Tidwell HC, Holt LE, Foman HL, et al:  Studies in fat metabolism: II. Fat absorption in premature infants and twins . J Pediatr 1935;;6:481-489.
16 +
Gordon HH, McNamara H:  Fat excretion of premature infants: I. Effect on fecal fat of decreasing fat intake . Am J Dis Child 1941;;62:328-345.
17 +
Davidson M, Bauer CH:  Pattern of fat excretion in feces of premature infants fed various preparations of milk . Pediatrics 1960;;25:375-384.
18 +
Hilditch TP: The Chemical Constitution of Natural Fats , ed 3. New York, John Wiley & Sons Inc, 1956;, p 343.
19 +
Holt LE, Tidwell HC, Kirk CM, et al:  Studies in fat metabolism: I. Fat absorption in normal infants . J Pediatr 1935;;6:427-481.
20 +
Kritchevsky D, Rabinowitz JL:  Influence of dietary fat on fatty acid biosynthesis in rat . Biochem Biophys Acta 1966;;116:185-188.
21 +
Shaw JCL:  Evidence for defective skeletal mineralization in low birth weight infants: The absorption of calcium and fat . Pediatrics 1976;;57:16-25.
22 +
Minton SD, Steichen JJ, Tsang RC:  Bone mineral content in term and preterm appropriate-for-gestational-age infants . J Pediatr 1979;;95:1037-1042.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Yamashita F, Shibuya S, Funatsu I, et al:  Absorption of medium-chain triglyceride in the low birth weight infant and evaluation of MCT milk formula for low birth weight infant nutrition using the Latin square technique . Kurume Med J 1969;;16:191-201.
2 +
Andrews BF, Lorch V:  Improved fat and calcium absorption in LBW infants fed a medium-chain triglyceride containing formula , abstracted. Pediatr Res 1974;;8:104.
3 +
Roy CC, Ste-Marie M, Chartrand L, et al:  Correction of the malabsorption of the preterm infants with a medium-chain triglyceride formula . J Pediatr 1975;;86:446-450.
4 +
Tantibhendyangkul P, Hashim SA:  Medium-chain triglyceride feeding in premature infants: Effects on fat and nitrogen absorption . Pediatrics 1975;;55:359-370.
5 +
Tantibhendyangkul P, Hashim SA:  Medium-chain triglyceride feeding in premature infants: Effects on calcium and magnesium absorption . Pediatrics 1978;;61:537-545.
6 +
Shenai PJ, Reynolds JW, Babson SG:  Nutritional balance studies in very-low-birth-weight infants: Enhanced nutrient retention rates by an experimental formula . Pediatrics 1980;;66:233-238.
7 +
Dubowitz LM, Dubowitz V, Goldberg C:  Clinical assessment of gestational age in the newborn infant . J Pediatr 1970;;77:1-10.
8 +
Jeejeebhoy KN, Ahmad S, Kozak G:  Determination of fecal fats containing both medium and long chain triglycerides and fatty acids . Clin Biochem 1970;;3:157-163.
9 +
Hansen JL, Freier EF:  The measurement of serum magnesium by atomic absorption spectrophotometry . Am J Tech 1967;;33:158-166.
10 +
Trudeau DL, Freier EF:  Determination of calcium in urine and serum by atomic absorption spectrophotometry . Clin Chem 1967;;13:101-114.
11 +
Snedecor GW, Cochran WG: Statistical Methods . Ames, Iowa, Iowa State University Press, 1967;, pp 258-298.
12 +
Watkins JB, Szczepanik P, Gould JB, et al:  Bile salt metabolism in the human premature infant . Gastroenterology 1975;;69:706-713.
13 +
Zoppi G, Andreotti G, Pajno-Ferrara F, et al:  Exocrine pancreas function in premature and full term neonates . Pediatr Res 1972;;6:880-886.
14 +
Greenberger NJ, Skillman TG:  Medium-chain triglycerides . N Engl J Med 1968;;280:1045-1058.
15 +
Tidwell HC, Holt LE, Foman HL, et al:  Studies in fat metabolism: II. Fat absorption in premature infants and twins . J Pediatr 1935;;6:481-489.
16 +
Gordon HH, McNamara H:  Fat excretion of premature infants: I. Effect on fecal fat of decreasing fat intake . Am J Dis Child 1941;;62:328-345.
17 +
Davidson M, Bauer CH:  Pattern of fat excretion in feces of premature infants fed various preparations of milk . Pediatrics 1960;;25:375-384.
18 +
Hilditch TP: The Chemical Constitution of Natural Fats , ed 3. New York, John Wiley & Sons Inc, 1956;, p 343.
19 +
Holt LE, Tidwell HC, Kirk CM, et al:  Studies in fat metabolism: I. Fat absorption in normal infants . J Pediatr 1935;;6:427-481.
20 +
Kritchevsky D, Rabinowitz JL:  Influence of dietary fat on fatty acid biosynthesis in rat . Biochem Biophys Acta 1966;;116:185-188.
21 +
Shaw JCL:  Evidence for defective skeletal mineralization in low birth weight infants: The absorption of calcium and fat . Pediatrics 1976;;57:16-25.
22 +
Minton SD, Steichen JJ, Tsang RC:  Bone mineral content in term and preterm appropriate-for-gestational-age infants . J Pediatr 1979;;95:1037-1042.

Correspondence

Submit a Letter
CME
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Clear Answers | Save For Later
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2013 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems