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Paraldehyde Toxicity During Treatment of Status Epilepticus

Bruce Bostrom, MD
Am J Dis Child. 1982;136(5):414-415. doi:10.1001/archpedi.1982.03970410032006.
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• A 2-month-old girl survived a lethal serum level of paraldehyde after being given the drug intravenously (IV) for status epilepticus. On the basis of known pharmacokinetic data in man, a slow IV infusion, over a period of five minutes, of 200 mg/kg of paraldehyde followed by a drip of 20 mg/kg/hr should result in safe, rapid control of status epilepticus when first-line anticonvulsant drugs have failed. The paraldehyde should be diluted to a 10% solution with 5% dextrose water.

(Am J Dis Child 1982;136:414-415)


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