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Cystic Fibrosis Mistaken for Gastroesophageal Reflux-Reply

Am J Dis Child. 1982;136(3):279. doi:10.1001/archpedi.1982.03970390093030.
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In Reply.—We thank Dr Sagall for his comments concerning our article (Journal 1981;135:719-720). On reflection, we agree with Dr Sagall that our conclusion in the abstract recommending quantitative pilocarpine iontophoresis sweat tests for "... all infants with possible GER...." is too inclusive. Perhaps, a more useful recommendation would be the performance of quantitative pilocarpine iontophoresis sweat tests on all infants with possible GER who are sick enough to warrant hospitalization, especially for those infants with respiratory tract symptoms or findings. Under these circumstances, a quantitative pilocarpine iontophoresis sweat test may prove to be cost-effective. For example, the cost of a quantitative pilocarpine iontophoresis sweat test is $34 at our medical center. If we had tested our two patients at admission and found that they had CF, both patients might have been spared the much greater cost and discomfort of hospitalization and extensive investigations of their vomiting and failure to thrive,


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