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Multiple Hepatic Hemangiomas: Failure of Corticosteroid Therapy and Successful Hepatic Artery Ligation

Am J Dis Child. 1982;136(3):275-276. doi:10.1001/archpedi.1982.03970390089025.
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Multinodular hemangiomatosis of the liver generally occurs in the first six months of life, with the triad of hepatomegaly, high-output congestive heart failure, and cutaneous hemangiomas.1 Early reviews described a poor prognosis with death, generally due to intractable congestive heart failure, occurring within the first year.1,2 More recent reports suggest that a favorable outcome usually results from vigorous supportive care and high-dose corticosteroid therapy.2-4 We have recently encountered two patients, however, who received long-term high-dose corticosteroid therapy without apparent response. In one instance, spontaneous involution and hemodynamic improvement was noted; in the other, hepatic artery ligation was performed successfully. Both patients are alive and well more than two years after diagnosis.

Report of Cases.—Case 1.—This infant was well until 3 months of age when poor feeding, respiratory distress, and two episodes of dusky skin color with feedings were noted. Physical examination disclosed an acutely ill


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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