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No Link Between Poland Syndrome and Leukemia? FREE

PRISCILLA A. GILMAN, MD; ROBERT W. MILLER, MD
Am J Dis Child. 1982;136(2):176. doi:10.1001/archpedi.1982.03970380088026.
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Sir.—In reporting the seventh case known with leukemia and Poland syndrome, or at least with absent pectoralis major muscle (APM), Enzenauer and Hastings (Journal 1981;135:763-765) suggested that the number of patients with both diseases in developed countries did not exceed the number expected by chance, as previously thought. Actually, six of these patients were born in the United States between 1962 and 1969, as best we can determine from the case reports or as confirmed by the original authors, and most were in the northeast (New York, Long Island, Newark, NJ, New Hampshire, Denver, and one unstated).

Among the 37.6 million births in the United States between 1962 and 1971, an estimated 7,000 had APM, given an incidence of 1.88 per 10,000 births for APM detected by 1 year of age in the Collaborative Perinatal Project at about the same time.1 The number of cases of leukemia expected

REFERENCES

Myrianthopoulos NC, Chung CS:  Congenital malformations in singletons: Epidemiologic survey in birth defects . Birth Defects 1974;;10:1-58.
Bader JL, Miller RW:  Neurofibromatosis and childhood leukemia . J Pediatr 1978;;92:925-929.
Miller RW, Fraumeni JF, Manning MD:  Association of Wilms' tumor with aniridia, hemihypertrophy and other congenital malformations . N Engl J Med 1964;;270:922-927.
Bader JL, Miller RW, Meadows AT, et al:  Trilateral retinoblastoma . Lancet 1980;;2:582-583.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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References

Myrianthopoulos NC, Chung CS:  Congenital malformations in singletons: Epidemiologic survey in birth defects . Birth Defects 1974;;10:1-58.
Bader JL, Miller RW:  Neurofibromatosis and childhood leukemia . J Pediatr 1978;;92:925-929.
Miller RW, Fraumeni JF, Manning MD:  Association of Wilms' tumor with aniridia, hemihypertrophy and other congenital malformations . N Engl J Med 1964;;270:922-927.
Bader JL, Miller RW, Meadows AT, et al:  Trilateral retinoblastoma . Lancet 1980;;2:582-583.

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