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Dysphagia as an Unusual Manifestation of Burkitt's Lymphoma FREE

ERIC SARIBAN, MD; IAN T. MAGRATH, MRCP
Am J Dis Child. 1982;136(2):171-172. doi:10.1001/archpedi.1982.03970380083019.
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Approximately 75% to 80% of American patients with Burkitt's lymphoma have abdominal tumor when seen initially, which in three quarters of the patients is localized to the gastrointestinal (GI) tract.1 The small intestine is most commonly involved, giving rise to abdominal pain, malaise, fatigue, anemia, and diarrhea. Intussusception is common, bleeding from the bowel is a frequent accompaniment, and perforation may rarely occur.

To our knowledge, only one patient, a 38-year-old man, has been described in the literature as having dysphagia as the first complaint in Burkitt's lymphoma.2 We report herein a second case in a male adolescent and review some of the differential diagnoses.

Report of a Case.—A 16-year-old boy was referred to the National Institutes of Health (NIH) with a diagnosis of lymphoma. Three months earlier he had begun to experience fatigue and loss of weight that was attributed by his physician to a viral

REFERENCES

Banks PM, Arseneau JC, Gralnick HR, et al:  American Burkitt's lymphoma: A clinicopathologic study of 30 cases . Am J Med 1975;;58:322-329.
Pitts JR, Cowley A:  Non-African Burkitt lymphoma presenting as dysphagia . Postgrad Med J 1977;;53:276-277.
Cohen LF, Balow JE, Magrath IT, et al:  Acute tumor lysis: A review of 36 patients with Burkitt's lymphoma . Am J Med 1980;;68:486-491.
Ziegler JL, Magrath IT, Deisseroth AB, et al:  Combined modality treatment of Burkitt's lymphoma . Cancer Treat Rep 1978;;62:2031-2034.
Burkitt D, O'Connor GT:  Malignant lymphoma in African children . Cancer 1961;;14:258-269.
Magrath IT, Ziegler JL:  Bone marrow involvement in Burkitt's lymphoma and its relationship to acute B-cell leukemia . Leukemia Res 1979;;4:35-59.
Levine PH, Kamaraju LS, Connelly RR, et al:  The American Burkitt's lymphoma registry: Eight years' experience . Cancer , to be published.
Cohen MH, Bennett JM, Berard CW, et al:  Burkitt's lymphoma in the United States . Cancer 1969;;23:1259-1272.
Cockshott WP:  Radiological aspects of Burkitt's tumour . Br J Radiol 1965;;38:172-180.
Silverman A, Roy CC, Cozzetto FJ: Pediatric Clinical Gastroenterology . St Louis, CV Mosby Co, 1971;, p 34.
Gryboski J: Major Problems in Clinical Pediatrics , Schaffer AJ, Markowitz M (eds). Philadelphia, WB Saunders Co, 1975;, vol 13, p 97.
DeMuth WE Jr:  Rhabdomyosarcoma of the esophagus . J Thorac Surg 1956;;32:115-118.
Johnston DP Jr, van Heerden JA, Lynn HB, et al:  Carcinoma of the stomach in a 10-year-old boy . J Pediatr Surg 1975;;10:151-152.
Al-Rashid RA, Harned RK:  Dysphagia due to leukemic involvement of the esophagus . Am J Dis Child 1971;;121:75-76.
Ming SC: Tumors of the Esophagus and Stomach . Atlas of Tumor Pathology, Armed Forces Institute of Pathology, 1973;, series 2, (pt 7) , p 75.

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References

Banks PM, Arseneau JC, Gralnick HR, et al:  American Burkitt's lymphoma: A clinicopathologic study of 30 cases . Am J Med 1975;;58:322-329.
Pitts JR, Cowley A:  Non-African Burkitt lymphoma presenting as dysphagia . Postgrad Med J 1977;;53:276-277.
Cohen LF, Balow JE, Magrath IT, et al:  Acute tumor lysis: A review of 36 patients with Burkitt's lymphoma . Am J Med 1980;;68:486-491.
Ziegler JL, Magrath IT, Deisseroth AB, et al:  Combined modality treatment of Burkitt's lymphoma . Cancer Treat Rep 1978;;62:2031-2034.
Burkitt D, O'Connor GT:  Malignant lymphoma in African children . Cancer 1961;;14:258-269.
Magrath IT, Ziegler JL:  Bone marrow involvement in Burkitt's lymphoma and its relationship to acute B-cell leukemia . Leukemia Res 1979;;4:35-59.
Levine PH, Kamaraju LS, Connelly RR, et al:  The American Burkitt's lymphoma registry: Eight years' experience . Cancer , to be published.
Cohen MH, Bennett JM, Berard CW, et al:  Burkitt's lymphoma in the United States . Cancer 1969;;23:1259-1272.
Cockshott WP:  Radiological aspects of Burkitt's tumour . Br J Radiol 1965;;38:172-180.
Silverman A, Roy CC, Cozzetto FJ: Pediatric Clinical Gastroenterology . St Louis, CV Mosby Co, 1971;, p 34.
Gryboski J: Major Problems in Clinical Pediatrics , Schaffer AJ, Markowitz M (eds). Philadelphia, WB Saunders Co, 1975;, vol 13, p 97.
DeMuth WE Jr:  Rhabdomyosarcoma of the esophagus . J Thorac Surg 1956;;32:115-118.
Johnston DP Jr, van Heerden JA, Lynn HB, et al:  Carcinoma of the stomach in a 10-year-old boy . J Pediatr Surg 1975;;10:151-152.
Al-Rashid RA, Harned RK:  Dysphagia due to leukemic involvement of the esophagus . Am J Dis Child 1971;;121:75-76.
Ming SC: Tumors of the Esophagus and Stomach . Atlas of Tumor Pathology, Armed Forces Institute of Pathology, 1973;, series 2, (pt 7) , p 75.

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