In Reply.—I wish to examine each feature for which Dr Jacobs claims priority of the associations of HLA-DRw5.
Uveitis: Suciu-Foca and her colleagues stated that "more patients with pauciarticular JRA [juvenile rheumatoid arthritis] and uveitis have to be HLA typed to confirm the strength of the association between this form of the disease and DR5." The numbers were not sufficient to associate uveitis particularly with female patients.1
Sex distribution: They were unable to find a significant difference in the occurrence of DR5 in male compared with female subjects.1
Predisposition for the knee: No statements were made in either of these articles1,2 indicating a predisposition for knee involvement.
Positive test result for antinuclear antibody: No data were given in either of these articles relating HLA-DR5 to antinuclear antibody.
Suciu-Foca et al1 made no statement to the effect that the patients studied tested negatively for