0
Article |

Down's Syndrome and Immune Function

A. L. RODRÍGUEZ DE LA NUEZ, MD; M. L. SUBIRÁ; T. SÁNCHEZ DOMÍNGUEZ, MD; I. VILLA-ELÍZAGA, MD
Am J Dis Child. 1982;136(1):81. doi:10.1001/archpedi.1982.03970370083027.
Text Size: A A A
Published online

Sir.—Spina et al (Journal 1981; 135:251-255) reported a study of immune function in Down's syndrome (DS), which showed markedly reduced B-lymphocyte and altered T-lymphocyte proliferative response to phytohemagglutinin (PHA). They suggested that the anomalies in DS immune function are similar to those found in aged normal subjects and may be the result from common environmental factors, such as exposure to infectious agents.

The influence of aging on immune function in DS, a fact well documented in recent literature (as Spina et al showed) moved us to study the possible immunological early defect in DS.

Forty-six children with DS, aged 12 to 46 months, noninstitutionalized, and without concurrent diseases, were tested.

Assessments were performed twice with a two-month interval, and results compared with 20 agematched, healthy control subjects. Our results, reported elsewhere,1 showed a normal humoral immunity in DS in infancy, with normal serum immunoglobulins and B cells (expressed both

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();