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December 1981, Vol 135, No. 12 >
Article | December 1981

Pneumococcal Vaccine Failure FREE

MARGARET K. HOSTETTER, MD; ALAN L. SCHWARTZ, MD; GEORGE R. SIBER, MD; GERALD SCHIFFMAN, PHD
Am J Dis Child. 1981;135(12):1149-1150. doi:10.1001/archpedi.1981.02130360053026.
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Sir.—A recent article in the Journal (1981;135:155-158) reviewed six cases of pneumococcal disease with vaccine serotypes. In the discussion of the authors' cases, one of us (M.K.H.) was quoted in reference to a case of nonvaccine pneumococcal meningitis occurring in a splenectomized, vaccinated child receiving penicillin prophylaxis. We now present the details of this child's illness and laboratory investigations, which include corroboration of compliance with oral antibiotic prophylaxis, quantitation of antigenemia, and measurement of premorbid, acute, and follow-up antibody titers to vaccine and infecting organisms.

Report of a Case.—A 10-year-old girl underwent surgical splenectomy at the age of 2 years for hypersplenism complicating β thalassemia. Immediately after her operation, oral antibiotic prophylaxis with penicillin V potassium, 250 mg twice a day, was begun. In February 1978 she also received 14-valent pneumococcal vaccine (Pneumovax); daily penicillin prophylaxis was continued.

On Dec 13, 1978, after initial improvement from a three-day

REFERENCES

1 +
Sabath LD, Casey JI, Ruch PA, et al:  Rapid microassay of gentamicin, kanamycin, neomycin, streptomycin, and vancomycin in serum or plasma . J Lab Clin Med 1971;;78:457-463.
2 +
Ward JI, Siber GR, Scheifele DW, et al:  Rapid diagnosis of Hemophilus influenzae type b infections by latex particle agglutination and counter immunoelectrophoresis . J Pediatr 1978;;93:37-42.
3 +
Durbin WA, Szymczak EG, Goldmann DA:  Quantitative blood cultures in ambulatory childhood bacteremia . J Pediatr 1978;;92:778-780.
4 +
Schiffman G, Austrian R:  A radioimmunoassay for the measurement of pneumococcal capsular antigens and antibodies thereto , abstracted. Fed Proc 1971;;30:658.
5 +
Burke JP, Klein JO, Gezon HM, et al:  Pneumococcal bacteremia: Review of 111 cases, 1957-1969, with special reference to cases with undetermined focus . Am J Dis Child 1971;;121:353-359.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Sabath LD, Casey JI, Ruch PA, et al:  Rapid microassay of gentamicin, kanamycin, neomycin, streptomycin, and vancomycin in serum or plasma . J Lab Clin Med 1971;;78:457-463.
2 +
Ward JI, Siber GR, Scheifele DW, et al:  Rapid diagnosis of Hemophilus influenzae type b infections by latex particle agglutination and counter immunoelectrophoresis . J Pediatr 1978;;93:37-42.
3 +
Durbin WA, Szymczak EG, Goldmann DA:  Quantitative blood cultures in ambulatory childhood bacteremia . J Pediatr 1978;;92:778-780.
4 +
Schiffman G, Austrian R:  A radioimmunoassay for the measurement of pneumococcal capsular antigens and antibodies thereto , abstracted. Fed Proc 1971;;30:658.
5 +
Burke JP, Klein JO, Gezon HM, et al:  Pneumococcal bacteremia: Review of 111 cases, 1957-1969, with special reference to cases with undetermined focus . Am J Dis Child 1971;;121:353-359.

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