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December 1981, Vol 135, No. 12 >
Article | December 1981

Ethotoin Use in Pediatric Seizure Patients FREE

BARBARA H. KORBERLY, PHARMD; THOMAS J. MRAZIK, PHARMD; LEONARD J. GRAZIANI, MD
Am J Dis Child. 1981;135(12):1139-1140. doi:10.1001/archpedi.1981.02130360043015.
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Ethotoin (Peganone), 3-ethyl, 5-phenylhydantoin, reportedly had less anticonvulsant activity in epileptic patients than the two more commonly used anticonvulsants, phenytoin sodium and phenobarbital.1 Phenytoin, an effective drug for treatment of generalized seizures other than absence, has several side effects, including gingival hyperplasia and hirsutism, which may reduce patient acceptance and compliance, especially in children and adolescents. Phenobarbital, with comparative anticonvulsant activity to phenytoin, is reported to cause behavioral disturbance, especially hyperactivity, in up to 42% of pediatric patients who receive the drug.2 By contrast, ethotoin has minimal side effects,1 but since its introduction in 1956 for the control of generalized seizures other than absence, it has not been studied extensively in epileptic children.3-5 These previous studies did not report therapeutic blood levels for ethotoin, and the dosage that was used ranged from 500 mg to 5 g daily.

In this communication, we review our experience with

REFERENCES

1 +
Goodman L, Gilman A: Pharmacologic Basis of Therapeutics , ed 5. New York, Macmillan Publishing Co Inc, 1975;, p 209.
2 +
Wolf S, Forsythe A:  Behavior disturbance, phenobarbital and febrile seizures . Pediatrics 1978;;61:728-731.
3 +
Livingston S:  The use of Peganone in the treatment of epilepsy . J Pediatr 1956;;49:728-732.
4 +
Zimmerman F, Burgemeister B:  Ethotoin, a new anticonvulsant . NY State J Med 1958;; 53:2054-2056.
5 +
Schwade ED, Richards RK, Everett GM:  Peganone, a new antiepileptic drug . Dis Nerv Syst 1956;;17:155-158.
6 +
Troupin AS, Friel P, Lovely MP, et al:  Clinical pharmacology of mephenytoin and ethotoin . Ann Neurol 1979;;6:410-414.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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References

1 +
Goodman L, Gilman A: Pharmacologic Basis of Therapeutics , ed 5. New York, Macmillan Publishing Co Inc, 1975;, p 209.
2 +
Wolf S, Forsythe A:  Behavior disturbance, phenobarbital and febrile seizures . Pediatrics 1978;;61:728-731.
3 +
Livingston S:  The use of Peganone in the treatment of epilepsy . J Pediatr 1956;;49:728-732.
4 +
Zimmerman F, Burgemeister B:  Ethotoin, a new anticonvulsant . NY State J Med 1958;; 53:2054-2056.
5 +
Schwade ED, Richards RK, Everett GM:  Peganone, a new antiepileptic drug . Dis Nerv Syst 1956;;17:155-158.
6 +
Troupin AS, Friel P, Lovely MP, et al:  Clinical pharmacology of mephenytoin and ethotoin . Ann Neurol 1979;;6:410-414.

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