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Salmonella Sepsis in Infancy

R. Craig Davis, MD
Am J Dis Child. 1981;135(12):1096-1099. doi:10.1001/archpedi.1981.02130360004003.
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• Of seven infants with Salmonella sepsis, three had meningitis. A review of these cases and others previously reported demonstrated that among infants less than 1 year old in Arkansas, Salmonella infection developed in 383 over a 3½-year period. The reported incidence of sepsis and/or meningitis was 1.8%; for those less than 2 months of age, it was 5.0%. Epidemiologic investigation failed to disclose a consistent source of the Salmonella colonization for young infants. Treatment of meningitis with ampicillin sodium was frequently associated with relapse or clinical failure, while chloramphenicol or a chloramphenicol-ampicillin combination appeared to offer superior efficacy. Consideration should be given to antibiotics for the routine treatment of Salmonella gastroenteritis in infants less than 3 months of age.

(Am J Dis Child 1981;135:1096-1099)


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