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November 1981, Vol 135, No. 11 >
Article | November 1981

Hearing Loss After Therapy With Radiation FREE

JAMES COPLAN, MD; ERNEST M. POST, MD; ROBERT A. RICHMAN, MD; CHARLES T. GRIMES, PHD
Am J Dis Child. 1981;135(11):1066-1067. doi:10.1001/archpedi.1981.02130350066021.
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Hearing loss has been noted as a complication of cranial irradiation in adults,1-7 but to our knowledge has not previously been described in children.8 We studied a preadolescent child in whom moderate to severe hearing loss developed after radiation therapy.

Report of a Case.—A 12-year-old girl had been in good health until 5 years of age, when she had begun to experience recurrent headaches. At age 6½ years, papilledema developed; skull roentgenograms showed a partially calcified suprasellar mass. She underwent subtotal resection of an optic glioma, and received postoperative radiation, 5,000 rad total tumor dose, in 25 fractions over five weeks. The radiation field included the petrous portion of both temporal bones. Examination immediately after therapy revealed alopecia in the left temporal region, and desquamation behind both pinnae. Over the following three months, headaches again developed that were treated with aspirin, 80 to 100 mg/kg/day. When

REFERENCES

1 +
Gyorkey J, Pollock FJ:  Radiation necrosis of the ossicles . Arch Otolaryngol 1960;;71:793-796.
2 +
Borsanyi S, Blanchard CL, Thorne B:  The effects of ionizing radiation on the ear . Ann Otol Rhinol Laryngol 1961;;70:255-262.
3 +
Borsanyi S:  The effects of radiation therapy on the ear . South Med J 1962;;55:740-743.
4 +
Leach W:  Irradiation of the ear . J Laryngol Otol 1965;;79:870-880.
5 +
Schuknecht HF, Karmody CS:  Radionecrosis of the temporal bone . Laryngoscope 1966;;76:1416-1428.
6 +
Dias A:  Effects on the hearing of patients treated by irradiation in the head and neck area . J Laryngol Otol 1966;;80:276-287.
7 +
Moretti JA:  Sensori-neural hearing loss following radiotherapy to the nasopharynx . Laryngoscope 1976;;86:598-602.
8 +
Gilbert HA, Kagan AR: Radiation Damage to the Nervous System . New York, Raven Press, 1980;, p 150.
9 +
Thibadoux GM, Pereira WV, Hodges JM:  Effects of cranial irradiation on hearing in children with acute lymphocytic leukemia . J Pediatr 1980;;96:403-406.
10 +
Mikhael M:  Radiation necrosis of the brain: Correlation between patterns on computed tomography and dose of radiation . J Comput Assist Tomogr 1979;;3:241-249.
11 +
Sheffield PA, Turner JS: Ototoxic drugs:  A review of histopathologic changes and mechanisms of action . South Med J 1971;;64:359-363.

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References

1 +
Gyorkey J, Pollock FJ:  Radiation necrosis of the ossicles . Arch Otolaryngol 1960;;71:793-796.
2 +
Borsanyi S, Blanchard CL, Thorne B:  The effects of ionizing radiation on the ear . Ann Otol Rhinol Laryngol 1961;;70:255-262.
3 +
Borsanyi S:  The effects of radiation therapy on the ear . South Med J 1962;;55:740-743.
4 +
Leach W:  Irradiation of the ear . J Laryngol Otol 1965;;79:870-880.
5 +
Schuknecht HF, Karmody CS:  Radionecrosis of the temporal bone . Laryngoscope 1966;;76:1416-1428.
6 +
Dias A:  Effects on the hearing of patients treated by irradiation in the head and neck area . J Laryngol Otol 1966;;80:276-287.
7 +
Moretti JA:  Sensori-neural hearing loss following radiotherapy to the nasopharynx . Laryngoscope 1976;;86:598-602.
8 +
Gilbert HA, Kagan AR: Radiation Damage to the Nervous System . New York, Raven Press, 1980;, p 150.
9 +
Thibadoux GM, Pereira WV, Hodges JM:  Effects of cranial irradiation on hearing in children with acute lymphocytic leukemia . J Pediatr 1980;;96:403-406.
10 +
Mikhael M:  Radiation necrosis of the brain: Correlation between patterns on computed tomography and dose of radiation . J Comput Assist Tomogr 1979;;3:241-249.
11 +
Sheffield PA, Turner JS: Ototoxic drugs:  A review of histopathologic changes and mechanisms of action . South Med J 1971;;64:359-363.

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