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Chronic Upper Airway Obstruction and Pulmonary Hypertension in Down's Syndrome

Thomas W. Rowland, MD; Leif G. Nordstrom, MD; Mark S. Bean, MD; Henry Burkhardt, MD
Am J Dis Child. 1981;135(11):1050-1052. doi:10.1001/archpedi.1981.02130350050016.
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• Precocious pulmonary hypertension in children with Down's syndrome may occur in patients with or without congenital heart disease. Chronic upper airway obstruction, which is common in Down's syndrome, is a well-recognized stimulus of elevated pulmonary artery pressure and may explain the propensity for idiopathic pulmonary hypertension or accelerated pulmonary vascular changes with left-to-right shunts in these children.

(Am J Dis Child 1981;135:1050-1052)

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