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Vitamin D Metabolism in Idiopathic Infantile Hypercalcemia

Dagfinn Aarskog, MD; Lage Aksnes, PhD; Trond Markestad, MD
Am J Dis Child. 1981;135(11):1021-1024. doi:10.1001/archpedi.1981.02130350025009.
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• A 9-month-old boy who had the mild form of idiopathic infantile hypercalcemia was observed for 18 months. During the initial hypercalcemic stage, the serum concentration of 25-hydroxyvitamin D was normal. Urinary levels of cyclic adenosine monophosphate (cAMP) were low, and the serum concentrations of the dihydroxyl metabolites of vitamin D were appropriate to the high serum calcium concentration, with low 1,25-dihydroxyvitamin D and relatively high 24,25- and 25,26-dihydroxyvitamin D levels. Throughout the study period, there was a close positive correlation between the magnitude of the urinary cAMP excretion and the serum level of 1,25-dihydroxyvitamin D. The results indicate that excessive vitamin D intake leading to high serum levels of 25-hydroxyvitamin D are not decisive factors in the pathogenesis of idiopathic infantile hypercalcemia.

(Am J Dis Child 1981;135:1021-1024)


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