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October 1981, Vol 135, No. 10 >
Article | October 1981

Influence of Age and Sex on Serum Complement Components in Children FREE

Barbara Roach; Youngki Kim, MD; Elizabeth Jerome, MD; Alfred F. Michael, MD
[+] Author Affiliations

Reprint requests to Department of Pediatrics, University of Minnesota Medical School, Box 491 Mayo, Minneapolis, MN 55455 (Dr Kim).


Am J Dis Child. 1981;135(10):918-920. doi:10.1001/archpedi.1981.02130340030011.
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• Concentrations of eight complement components were determined on sera from 419 healthy children (198 boys and 221 girls) aged from 1 to 19 years. A significant correlation between concentration and age for all complement components (C1q, C1s, C4, C3, C5, factor B, properdin, and C[unk] inhibitor) was observed for girls; in the male population, a significant correlation was present only for C1q, C4, C3, C5, and properdin. The presence of a significant relationship to age suggests that this variable must be considered in establishing normal values of serum complement for children.

(Am J Dis Child 1981;135:918-920)

REFERENCES

1 +
Fireman P, Zuchowsky DA, Taylor PM:  Development of the human complement system . J Immunol 1969;;103:25-31.
2 +
Ballow M, Fang F, Good RA, et al:  Developmental aspects of complement components in the newborn . Clin Exp Immunol 1974;;18:257-266.
3 +
Minta JO, Jezyk PD, Lepow IH:  Distribution and levels of properdin in human body fluids . Clin Immunol Immunopathol 1976;;5:84-90.
4 +
Norman ME, Gall EP, Taylor A, et al:  Serum complement profiles in infants and children . J Pediatr 1975;;87:912-916.
5 +
Kaufman HS, Frick OL, Fink D:  Serum complement (BIC) in young children with atopic dermatitis . J Allergy 1968;;42:1-8.
6 +
Davis CA, Vallota EH, Forristal J:  Serum complement levels in infancy: Age related changes . Pediatr Res 1979;;13:1043-1046.
7 +
Kim Y, Miller K, Michael AF:  Breakdown products of C3 and factor B in hemolytic-uremic syndrome . J Lab Clin Med 1977;;89:845-850.
8 +
Propp RP, Alper CA:  C'3 synthesis in the human fetus and lack of transplacental passage . Science 1968;;162:672-673.
9 +
Ewald RA, Williams JH, Bowden DH:  Serum complement in the newborn . Vox Sang 1961;;6:312-319.
10 +
Feinstein PA, Kaplan SR:  The alternate pathway of complement activation in the neonate . Pediatr Res 1975;;9:803-806.
11 +
Fishel CW, Pearlman DS:  Complement components of paired mother-cord sera . Proc Soc Exp Biol Med 1961;;107:695-699.
12 +
Adinolfi M:  Human complement: Onset and site of synthesis during fetal life . Am J Dis Child 1977;;131:1015-1023.
13 +
Coker SB, Nunnery AW, Wenzl JE:  Determination of B1C/B1A globulin in children . South Med J 1972;;65:61-64.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Fireman P, Zuchowsky DA, Taylor PM:  Development of the human complement system . J Immunol 1969;;103:25-31.
2 +
Ballow M, Fang F, Good RA, et al:  Developmental aspects of complement components in the newborn . Clin Exp Immunol 1974;;18:257-266.
3 +
Minta JO, Jezyk PD, Lepow IH:  Distribution and levels of properdin in human body fluids . Clin Immunol Immunopathol 1976;;5:84-90.
4 +
Norman ME, Gall EP, Taylor A, et al:  Serum complement profiles in infants and children . J Pediatr 1975;;87:912-916.
5 +
Kaufman HS, Frick OL, Fink D:  Serum complement (BIC) in young children with atopic dermatitis . J Allergy 1968;;42:1-8.
6 +
Davis CA, Vallota EH, Forristal J:  Serum complement levels in infancy: Age related changes . Pediatr Res 1979;;13:1043-1046.
7 +
Kim Y, Miller K, Michael AF:  Breakdown products of C3 and factor B in hemolytic-uremic syndrome . J Lab Clin Med 1977;;89:845-850.
8 +
Propp RP, Alper CA:  C'3 synthesis in the human fetus and lack of transplacental passage . Science 1968;;162:672-673.
9 +
Ewald RA, Williams JH, Bowden DH:  Serum complement in the newborn . Vox Sang 1961;;6:312-319.
10 +
Feinstein PA, Kaplan SR:  The alternate pathway of complement activation in the neonate . Pediatr Res 1975;;9:803-806.
11 +
Fishel CW, Pearlman DS:  Complement components of paired mother-cord sera . Proc Soc Exp Biol Med 1961;;107:695-699.
12 +
Adinolfi M:  Human complement: Onset and site of synthesis during fetal life . Am J Dis Child 1977;;131:1015-1023.
13 +
Coker SB, Nunnery AW, Wenzl JE:  Determination of B1C/B1A globulin in children . South Med J 1972;;65:61-64.

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