0
September 1981, Vol 135, No. 9 >
Article | September 1981

Abscesses Complicating DTP Vaccination FREE

Roger H. Bernier, PhD, MPH; John A. Frank, MD; Timothy F. Nolan, MD
[+] Author Affiliations

Reprint requests to Immunization Division, Center for Prevention Services, Centers for Disease Control, Atlanta, GA 30333 (Dr Bernier).


Am J Dis Child. 1981;135(9):826-828. doi:10.1001/archpedi.1981.02130330036011.
Text Size: A A A
Published online
Article
References
Comments

• Reports of abscesses after the use of diphtheria and tetanus toxoids and pertussis vaccine (DTP vaccine) from two different lots (No. 1 and 2) of a single manufacturer (manufacturer A) prompted an investigation into the rates of abscess formation following the use of DTP vaccine from several different manufacturers. A total of 74 abscesses for lot 1, 16 for lot 2, and three for other DTP products was uncovered. The overall rate after lots 1 and 2 was 1.1 per 1,000 doses administered compared with 0.01 per 1,000 doses for DTP vaccine from other manufacturers (P<.0001). Faulty technique, site and route of inoculation, microbiologic contamination, and hypersensitivity were ruled out as likely explanations for the increase in abscesses among recipients of DTP vaccine from manufacturer A. Use of a single needle to withdraw vaccine from the vial and to inoculate the vaccinees, combined with high aluminum adjuvant content in the implicated vaccine, may have led to an increased rate of abscess formation.

(Am J Dis Child 1981;135:826-828)

REFERENCES

1 +
Harrison WT:  Prophylactic value of a single dose of precipitated pertussis vaccine . Public Health Rep 1938;;53:793-796.
2 +
Bell JA:  Pertussis prophylaxis with two doses of alum precipitated vaccine . Public Health Rep 1941;;56:1535-1546.
3 +
Kendrick PL:  Use of alum treated pertussis vaccine, and of alum-precipitated combined pertussis vaccine and diphtheria toxoid, for active immunization . Am J Public Health 1942;;32:615-626.
4 +
Sako W, Trueting WL, Witt DB, et al:  Early immunization against pertussis with alum precipitated vaccine . JAMA 1945;;12:379-384.
5 +
McComb JA, Trafton MZ:  Immune responses and reactions to diphtheria and tetanus toxoids, with pertussis vaccine, aluminum phosphate precipitated . N Engl J Med 1950;;243:442-444.
6 +
Bousfield G:  A future for combined diphtheria and whooping cough prophylaxis . Med Off 1952;;87:265-267.
7 +
Medical Research Council:  The prevention of whooping cough by vaccination . Br Med J 1951;;1:1463-1471.
8 +
Diphtheria and Pertussis Vaccination , Technical Report Series No. 61. Geneva, World Health Organization, 1953;.
9 +
Sauer LW, Tucker WH:  Immune responses to diphtheria, tetanus, and pertussis, aluminum phosphate adsorbed . Am J Public Health 1954;;44:784-788.
10 +
Barr M, Glenny AT, Butler NR:  Immunization of babies with diphtheria tetanus pertussis prophylactic . Br Med J 1955;;2:635-639.
11 +
Volk VK, Top FH, Bunney WE:  Significance of cysts following injections of antigens . Am J Public Health 1954;;44:1314-1325.
12 +
Aprile MA, Wardlaw AC:  Aluminum compounds as adjuvants for vaccines and toxoids in man: A review . Can J Public Health 1966;;57:343-354.
13 +
Sauer LW:  Immunization in early childhood . IMJ 1950;;97:73-76.
14 +
Joo I: Mineral carriers as adjuvants. Read before the Conference on Vaccination Against Communicable Diseases, Monte Carlo, Monaco, March 1973.
15 +
Middaugh JP:  Side effects of diphtheria-tetanus toxoid in adults . Am J Public Health 1979;;69:246-249.
16 +
Butler NR, Voyce MA, Burland WL, et al:  Advantages of aluminum hydroxide adsorbed combined diphtheria tetanus and pertussis vaccine for the immunization of infants . Br Med J 1969;;1:663-666.
17 +
Borghaus JG, Stanford JL:  Mycobacterium chelonei in abscesses after injection of diphtheria-pertussis-tetanus-polio vaccine . Am Rev Respir Dis 1973;;107:1-8.
18 +
Vessal S, Kravis LP:  Immunologic mechanisms responsible for adverse reactions to routine immunizations in children . Clin Pediatr 1976;;15:688-696.
19 +
Sako W:  Studies in pertussis immunization . J Pediatr 1947;;30:29-40.
20 +
Strom J:  Further experience of reactions, especially of a cerebral nature, in conjunction with triple vaccination: A study based on vaccination in Sweden 1959-65 . Br Med J 1967;;4:320-323.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Harrison WT:  Prophylactic value of a single dose of precipitated pertussis vaccine . Public Health Rep 1938;;53:793-796.
2 +
Bell JA:  Pertussis prophylaxis with two doses of alum precipitated vaccine . Public Health Rep 1941;;56:1535-1546.
3 +
Kendrick PL:  Use of alum treated pertussis vaccine, and of alum-precipitated combined pertussis vaccine and diphtheria toxoid, for active immunization . Am J Public Health 1942;;32:615-626.
4 +
Sako W, Trueting WL, Witt DB, et al:  Early immunization against pertussis with alum precipitated vaccine . JAMA 1945;;12:379-384.
5 +
McComb JA, Trafton MZ:  Immune responses and reactions to diphtheria and tetanus toxoids, with pertussis vaccine, aluminum phosphate precipitated . N Engl J Med 1950;;243:442-444.
6 +
Bousfield G:  A future for combined diphtheria and whooping cough prophylaxis . Med Off 1952;;87:265-267.
7 +
Medical Research Council:  The prevention of whooping cough by vaccination . Br Med J 1951;;1:1463-1471.
8 +
Diphtheria and Pertussis Vaccination , Technical Report Series No. 61. Geneva, World Health Organization, 1953;.
9 +
Sauer LW, Tucker WH:  Immune responses to diphtheria, tetanus, and pertussis, aluminum phosphate adsorbed . Am J Public Health 1954;;44:784-788.
10 +
Barr M, Glenny AT, Butler NR:  Immunization of babies with diphtheria tetanus pertussis prophylactic . Br Med J 1955;;2:635-639.
11 +
Volk VK, Top FH, Bunney WE:  Significance of cysts following injections of antigens . Am J Public Health 1954;;44:1314-1325.
12 +
Aprile MA, Wardlaw AC:  Aluminum compounds as adjuvants for vaccines and toxoids in man: A review . Can J Public Health 1966;;57:343-354.
13 +
Sauer LW:  Immunization in early childhood . IMJ 1950;;97:73-76.
14 +
Joo I: Mineral carriers as adjuvants. Read before the Conference on Vaccination Against Communicable Diseases, Monte Carlo, Monaco, March 1973.
15 +
Middaugh JP:  Side effects of diphtheria-tetanus toxoid in adults . Am J Public Health 1979;;69:246-249.
16 +
Butler NR, Voyce MA, Burland WL, et al:  Advantages of aluminum hydroxide adsorbed combined diphtheria tetanus and pertussis vaccine for the immunization of infants . Br Med J 1969;;1:663-666.
17 +
Borghaus JG, Stanford JL:  Mycobacterium chelonei in abscesses after injection of diphtheria-pertussis-tetanus-polio vaccine . Am Rev Respir Dis 1973;;107:1-8.
18 +
Vessal S, Kravis LP:  Immunologic mechanisms responsible for adverse reactions to routine immunizations in children . Clin Pediatr 1976;;15:688-696.
19 +
Sako W:  Studies in pertussis immunization . J Pediatr 1947;;30:29-40.
20 +
Strom J:  Further experience of reactions, especially of a cerebral nature, in conjunction with triple vaccination: A study based on vaccination in Sweden 1959-65 . Br Med J 1967;;4:320-323.

Correspondence

Submit a Letter
CME
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Clear Answers | Save For Later
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2013 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems