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August 1981, Vol 135, No. 8 >
Article | August 1981

Neutrophil Functions and Mitogenic Response to Ascaris Antigen in Visceral Larva Migrans FREE

GIUSEPPE MAGGIORE, MD; FULVIO SACCHI, MD; LUIGI NESPOLI, MD; RITA MACCARIO
Am J Dis Child. 1981;135(8):770. doi:10.1001/archpedi.1981.02130320078030.
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Sir.—We were very interested in the report by Caldwell et al (Journal 1980;134:845-847) on neutrophil functions and mitogenic response to parasitic antigens in visceral larva migrans (VLM).

We studied neutrophil functions and lymphocyte mitogenic response to Ascaris suum extracts in a 3-year-old patient with VLM.1

Neutrophil chemotaxis using Escherichia coli-lipolysaccharide—activated human normal serum as chemoattractant was persistently defective and the IgE level always high (> 1,000 IU/mL); transient defects of bactericidal activity and metabolic activation, present at the onset, disappeared after therapy.

As suggested by Hill and Quie,2 the high IgE level may also have been responsible in our patient for the chemotaxis defect.

Ascaris suum extracts have been used as an effective carrier and adjuvant for IgE production against various antigens in animals.3

The mitogenic response of peripheral blood lymphocytes (PBL) of our patient to various mitogens (phytohemagglutinin, concanavalin A, and pokeweed mitogen) was

REFERENCES

1 +
Maggiore G, Sacchi F, Marconi M, et al:  Functional defects on neutrophils in viscera larva migrans syndrome . Infection 1980;;4:171-173.
2 +
Hill HR, Quie PG:  Raised serum IgE levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections . Lancet 1974;;1:183-187.
3 +
Ishizaka K:  Cellular events in the IgE antibody response . Ad v Immunol 1976;;23:1-75.
4 +
Nespoli L, Maccario R, Ferrari F, et al:  Ascaris suum extract: Polyclonal activator properties as possible tool for investigating in vitro IgE production in humans , in Ring J, Burg G, (eds): New Trends in Allergy . München, Germany, JF Bergmann Verlag, 1981;, pp 254-257.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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References

1 +
Maggiore G, Sacchi F, Marconi M, et al:  Functional defects on neutrophils in viscera larva migrans syndrome . Infection 1980;;4:171-173.
2 +
Hill HR, Quie PG:  Raised serum IgE levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections . Lancet 1974;;1:183-187.
3 +
Ishizaka K:  Cellular events in the IgE antibody response . Ad v Immunol 1976;;23:1-75.
4 +
Nespoli L, Maccario R, Ferrari F, et al:  Ascaris suum extract: Polyclonal activator properties as possible tool for investigating in vitro IgE production in humans , in Ring J, Burg G, (eds): New Trends in Allergy . München, Germany, JF Bergmann Verlag, 1981;, pp 254-257.

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