0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Neutrophil Functions and Mitogenic Response to Ascaris Antigen in Visceral Larva Migrans

GIUSEPPE MAGGIORE, MD; FULVIO SACCHI, MD; LUIGI NESPOLI, MD; RITA MACCARIO
Am J Dis Child. 1981;135(8):770. doi:10.1001/archpedi.1981.02130320078030.
Text Size: A A A
Published online

Sir.—We were very interested in the report by Caldwell et al (Journal 1980;134:845-847) on neutrophil functions and mitogenic response to parasitic antigens in visceral larva migrans (VLM).

We studied neutrophil functions and lymphocyte mitogenic response to Ascaris suum extracts in a 3-year-old patient with VLM.1

Neutrophil chemotaxis using Escherichia coli-lipolysaccharide—activated human normal serum as chemoattractant was persistently defective and the IgE level always high (> 1,000 IU/mL); transient defects of bactericidal activity and metabolic activation, present at the onset, disappeared after therapy.

As suggested by Hill and Quie,2 the high IgE level may also have been responsible in our patient for the chemotaxis defect.

Ascaris suum extracts have been used as an effective carrier and adjuvant for IgE production against various antigens in animals.3

The mitogenic response of peripheral blood lymphocytes (PBL) of our patient to various mitogens (phytohemagglutinin, concanavalin A, and pokeweed mitogen) was

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

* * SCHEDULED MAINTENANCE * *

Our websites may be periodically unavailable between midnight and 04:00 ET Thursday, July 10th, for regularly scheduled maintenance.

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();