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August 1981, Vol 135, No. 8 >
Article | August 1981

Carbamazepine Overdose FREE

SANDRA NUSINOFF LEHRMAN, MD; MARGARET L. BAUMAN, MD
Am J Dis Child. 1981;135(8):768-769. doi:10.1001/archpedi.1981.02130320076027.
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Carbamazepine (Tegretol) is frequently used in the treatment of grand mal and complex partial seizures. The drug has proven efficacy and relatively few serious side effects. Life-threatening toxicity has been rare with conventional use of carbamazepine, although aplastic anemia1 and heart block2-4 have occurred in elderly patients receiving the drug for trigeminal neuralgia. Fatal hepatitis has been documented in a 14-year-old girl who received the drug for six months,5 and aplastic anemia has been documented in an 18-year-old patient. However, serious complications during routine use are unusual.

The toxicity of carbamazepine in relationship to usual therapeutic regimens has been well documented. A review of the literature, however, discloses no reports of intentional or accidental ingestion of large amounts of this drug. We report a case of carbamazepine overdose in an adolescent girl.

Report of a Case.—A 14-year-old girl was brought to the emergency room by

REFERENCES

1 +
Troupin A:  The choice of anticonvulsants: A logical approach to sequential changes—a comment from an American neurologist , in Laidlaw J, Richens A (eds): Textbook of Epilepsy . New York, Churchill Livingstone, 1976;, pp 248-270.
2 +
Beermann B, Edhag O, Vallin H:  Advanced heart block aggravated by carbamazepine . Br Heart J 1975;;37:668-671.
3 +
Herzbert L:  Carbamazepine and bradycardia . Lancet 1978;;1:1097.
4 +
Hamilton DN:  Carbamazepine and heart block . Lancet 1978;;1:1365.
5 +
Zucker P, Daum F, Cohen MJ:  Fatal carbamazepine hepatitis . J Pediatr 1977;;91:667-668.
6 +
Salcman M, Pippenger C:  Acute carbamazepine encephalopathy . JAMA 1975;;231:915.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Troupin A:  The choice of anticonvulsants: A logical approach to sequential changes—a comment from an American neurologist , in Laidlaw J, Richens A (eds): Textbook of Epilepsy . New York, Churchill Livingstone, 1976;, pp 248-270.
2 +
Beermann B, Edhag O, Vallin H:  Advanced heart block aggravated by carbamazepine . Br Heart J 1975;;37:668-671.
3 +
Herzbert L:  Carbamazepine and bradycardia . Lancet 1978;;1:1097.
4 +
Hamilton DN:  Carbamazepine and heart block . Lancet 1978;;1:1365.
5 +
Zucker P, Daum F, Cohen MJ:  Fatal carbamazepine hepatitis . J Pediatr 1977;;91:667-668.
6 +
Salcman M, Pippenger C:  Acute carbamazepine encephalopathy . JAMA 1975;;231:915.

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