Article |

Hemolytic-Uremic Syndrome in Two Siblings From a Nonendemic Area

Am J Dis Child. 1981;135(8):766-767. doi:10.1001/archpedi.1981.02130320074025.
Text Size: A A A
Published online

The hemolytic-uremic syndrome (HUS) has been recognized as a cause of acute renal failure in infancy and childhood since 1955.1 The syndrome is characterized by a diarrheal prodrome, microangiopathic hemolytic anemia, thrombocytopenia, and renal failure. Numerous articles from both endemic2.3 and nonendemic4.5 regions have reported the broad spectrum of severity of this disease. However, relatively little emphasis has been given to the tendency of this disorder to occur in siblings. This article reports HUS in two brothers from a nonendemic area and demonstrates the variations in severity of this disease.

Report of Cases.—Case 1.—A 4-year-old boy was admitted to Henrietta Egleston Hospital for Children, Atlanta, after bloody diarrhea, vomiting, and increasing lethargy of five days' duration. Bloodtinged urine had developed the day prior to admission. Physical examination showed a lethargic but easily aroused child. The blood pressure (BP) was 96/62 mm Hg. The conjunctivae were mildly


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.