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July 1981, Vol 135, No. 7 >
Article | July 1981

Monitoring Salivary Theophylline Levels FREE

PETER GAL; NORMAN H. LEEDS
Am J Dis Child. 1981;135(7):671. doi:10.1001/archpedi.1981.02130310073026.
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Correspondence pertaining to material published in the Journal will be published, if found suitable, as space permits. Submit double-spaced copy clearly marked "For publication" and signed by all authors; references should conform to Journal format; maximum length: 500 words. Copyright assignment signed by all authors is required. The Editor reserves the right to edit such letters, which should be received within six weeks of publication of the Journal article in question. Sir.—We read with interest the report of Kelly et al, "Monitoring Children on Sustained-Release Therapy by Salivary Theophylline Levels" (Journal 1981;135:137-139). Despite several encouraging reports on the usefulness and reliability of salivary theophylline concentrations,1,2 subsequent studies have failed to support these findings.3 In a recent investigation of the bio-availability and release pattern of a sustained-release theophylline (TheoDur), we had the opportunity to examine serum-saliva theophylline ratios in six healthy young adults.

Subjects were administered theophylline, 600

REFERENCES

1 +
Koysooko R, Ellis EF, Levy G:  Relationship between theophylline concentration in plasma and saliva in man . Clin Pharmacol Ther 1971;;15:454-460.
2 +
Galant SP, Gillman SA, Cummins L, et al:  Reliability of salivary theophylline as a guide to plasma theophylline levels . Am J Dis Child 1977;;131:970-972.
3 +
Hendeles L, Burkey S, Bightey L:  Unpredictability of theophylline saliva measurements in chronic obstructive pulmonary disease . J Allergy Clin Immunol 1977;;60:335-338.
4 +
Orcutt JJ, Kozack PP, Gillman SA, et al:  Microscale method for theophylline in body fluids by reversed-phase high pressure liquid chromatography . Clin Chem 1977;;23:599-601.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Koysooko R, Ellis EF, Levy G:  Relationship between theophylline concentration in plasma and saliva in man . Clin Pharmacol Ther 1971;;15:454-460.
2 +
Galant SP, Gillman SA, Cummins L, et al:  Reliability of salivary theophylline as a guide to plasma theophylline levels . Am J Dis Child 1977;;131:970-972.
3 +
Hendeles L, Burkey S, Bightey L:  Unpredictability of theophylline saliva measurements in chronic obstructive pulmonary disease . J Allergy Clin Immunol 1977;;60:335-338.
4 +
Orcutt JJ, Kozack PP, Gillman SA, et al:  Microscale method for theophylline in body fluids by reversed-phase high pressure liquid chromatography . Clin Chem 1977;;23:599-601.

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