Intestinal Colic and Diarrhea as Side Effects of Intravenous Alprostadil Administration FREE

KORAVANGATTU SANKARAN, MB; JOHN CONLY, MD; CAROL A. J. BOYLE, MD; MICHAEL TYRRELL, MD

Am J Dis Child. 1981;135(7):664-665. doi:10.1001/archpedi.1981.02130310068023.

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ABSTRACT

ABSTRACT | REFERENCES

Prostaglandin E, produces substantial relaxation of the ductus arteriosus both in vivo and in vitro.^1-3 This has prompted its use in the management of certain congenital heart defects in neonates. The required dosage for maintaining ductal patency has been well described.^3,4 Side effects include pyrexia, hypotension, bradycardia, tachypnea, apneic spells, and erythema at the site of injection.^3,5,6 The purpose of this communication is to report intestinal colic, diarrhea, and irritability as additional side effects of alprostadil (prostaglandin E₁) administration.

Report of Cases.—Case 1.—A full-term baby boy was seen shortly after birth. Pregnancy and delivery were uneventful and birth weight was 2,550 g. At about 24 hours of age, severe central cyanosis was noted. Cardiac catheterization disclosed d-transposition of the great arteries and a patent ductus arteriosus. An interatrial balloon septostomy was done at the time of catheterization but failed to produce any substantial rise in

REFERENCES

ABSTRACT | REFERENCES

Coceani F, Olley PM: The response of the ductus arteriosus to prostaglandins . Can J Pharmacol 1973;;51:220-225.

Sharpe GL, Larsson KS: Studies on closure of the ductus arteriosus x in vitro effect of prostaglandin . Prostaglandins 1975;;9:703-720.

Schleman MM, Casta A, Mongkolsmai C, et al: Prostaglandin E, in the neonate with heart disease . Adv Prostaglandin Thromboxane Res 1980;;7:879-881.

Coceani F, Olley PM, Perin E: The response of the ductus arteriosus to E-type prostaglandins: An unique pattern, abstracted . Clin Res 1974;;22:722A.

Oliver TK, Kirschbaum TH, Haymann M (eds): Symposium on prostaglandins part 1 . Semin Perinatol 1980;;4:73-83.

Oliver TK, Kirschbaum TH, Haymann M (eds): Symposium on prostaglandins part 2 . Semin Perinatol 1980;;4:135-141.

Bennett A, Fleshier B: Action of prostaglandin E, on the longitudinal muscle of the guinea pig isolated colon . Br J Pharmacol 1969;;35:351-354.

Bennett A, Fleshier B: Prostaglandins and the gastrointestinal tract . Gastroenterology 1970;;59:790-793.

Bennett AM, Eby KG, Scholes GB: Effects of prostaglandins E, and E, on human, guinea pig and rat isolated small intestine . Br J Pharmacol 1968;;34:630-635.

Horton DW, Main IHM, Thompson CJ, et al: Effects of orally administered PGE, on gastric secretion and gastro-intestinal motility in man . Gut 1968;;9:655-658.

Miciewicz JJ, Walker SL, Kiley N, et al: Effect of oral PGE, on intestinal transit in man . Lancet 1969;;1:648-649.

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Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal