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June 1981, Vol 135, No. 6 >
Article | June 1981

Clinical and Chemical Correlates of the Bilirubin-Binding Capacity in Newborns FREE

Alex F. Robertson, MD; Warren B. Karp, PhD, DMD; Chantrapa Bunyapen, MD; William Zack Catterton, MD; Harry C. Davis, MS
[+] Author Affiliations

Reprint requests to Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912 (Dr Robertson).


Am J Dis Child. 1981;135(6):525-528. doi:10.1001/archpedi.1981.02130300025010.
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References
Comments

• We correlated commonly measured clinical and chemical variables in sick neonates to the total bilirubin-binding capacity (TBBC) measured with the peroxidase method. The significant correlations related to the infants' maturity and degree of illness. The factors having the strongest relation to TBBC were Apgar scores, total plasma albumin and bilirubin levels, gestational age, birth weight, use of ventilatory assistance, and maternal general anesthesia.

(Am J Dis Child 1981;135:525-528)

REFERENCES

1 +
Gartner L, Synder R, Chabon R, et al:  Kernicterus: High incidence in premature infants with low serum bilirubin concentrations . Pediatrics 1970;;45:906-917.
2 +
Turkel S, Guttenberg M, Moynes D, et al:  Lack of identifiable risk factors for kernicterus . Pediatrics 1980;;66:502-506.
3 +
Bloomer J, Berk P, Vergalla J, et al:  Influence of albumin on the extravascular distribution of unconjugated bilirubin . Clin Sci Mol Med 1973;;45:517-526.
4 +
Schmid R, Diamond I, Hammaker L, et al:  Interaction of bilirubin with albumin . Nature 1965;;206:1041-1043.
5 +
Diamond I, Schmid R:  Experimental bilirubin encephalopathy: The mode of entry of bilirubin-14C into the central nervous system . J Clin Invest 1966;;45:678-689.
6 +
Cashore W, Gartner L, Oh W, et al:  Clinical application of neonatal bilirubin binding determination: Current status . J Pediatr 1978;;93:827-833.
7 +
Gitzelmann-Cumarasamy N, Kuenzle C:  Bilirubin binding tests: Living up to expectations? Pediatrics 1979;;64:375-378.
8 +
Karp W:  Biochemical alterations in neonatal hyperbilirubinemia and bilirubin encephalopathy: A review . Pediatrics 1979;;64:361-368.
9 +
Levine R:  Bilirubin: Worked out years ago? Pediatrics 1979;;64:380-385.
10 +
Jacobsen J, Wennberg R:  Determination of unbound bilirubin in the serum of newborns . Clin Chem 1974;;20:783-789.
11 +
Cashore W, Monin P, Oh W:  Serum bilirubin binding capacity and free bilirubin concentration: A comparison between Sephadex G-25 filtration and peroxidase oxidation techniques . Pediatr Res 1978;;12:195-198.
12 +
Doumas B, Watson W, Biggs H:  Albumin standards and the measurement of serum albumin with bromcresol green . Clin Chim Acta 1971;;31:87-96.
13 +
Cattin P:  Note on the estimation of the squared cross-validated multiple correlation of a regression model . Psychol Bull 1980;;87:63-65.
14 +
Maisels M:  Bilirubin . Pediatr Clin North Am 1972;;19:447-501.
15 +
Kierney C, Ainbender E, Brown J, et al:  Comparison of measured and calculated serum bilirubin binding capacity (BBC): A danger exposed . Pediatr Res 1977;;11:536.
16 +
Cashore WJ, Horwich A, Karotkin EH, et al:  Influence of gestational age and clinical status on bilirubin-binding capacity in newborn infants: Sephadex G-25 gel filtration technique . Am J Dis Child 1977;;131:898-901.
17 +
Cashore W:  Free bilirubin concentrations and bilirubin-binding affinity in term and preterm infants . J Pediatr 1980;;96:521-527.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Gartner L, Synder R, Chabon R, et al:  Kernicterus: High incidence in premature infants with low serum bilirubin concentrations . Pediatrics 1970;;45:906-917.
2 +
Turkel S, Guttenberg M, Moynes D, et al:  Lack of identifiable risk factors for kernicterus . Pediatrics 1980;;66:502-506.
3 +
Bloomer J, Berk P, Vergalla J, et al:  Influence of albumin on the extravascular distribution of unconjugated bilirubin . Clin Sci Mol Med 1973;;45:517-526.
4 +
Schmid R, Diamond I, Hammaker L, et al:  Interaction of bilirubin with albumin . Nature 1965;;206:1041-1043.
5 +
Diamond I, Schmid R:  Experimental bilirubin encephalopathy: The mode of entry of bilirubin-14C into the central nervous system . J Clin Invest 1966;;45:678-689.
6 +
Cashore W, Gartner L, Oh W, et al:  Clinical application of neonatal bilirubin binding determination: Current status . J Pediatr 1978;;93:827-833.
7 +
Gitzelmann-Cumarasamy N, Kuenzle C:  Bilirubin binding tests: Living up to expectations? Pediatrics 1979;;64:375-378.
8 +
Karp W:  Biochemical alterations in neonatal hyperbilirubinemia and bilirubin encephalopathy: A review . Pediatrics 1979;;64:361-368.
9 +
Levine R:  Bilirubin: Worked out years ago? Pediatrics 1979;;64:380-385.
10 +
Jacobsen J, Wennberg R:  Determination of unbound bilirubin in the serum of newborns . Clin Chem 1974;;20:783-789.
11 +
Cashore W, Monin P, Oh W:  Serum bilirubin binding capacity and free bilirubin concentration: A comparison between Sephadex G-25 filtration and peroxidase oxidation techniques . Pediatr Res 1978;;12:195-198.
12 +
Doumas B, Watson W, Biggs H:  Albumin standards and the measurement of serum albumin with bromcresol green . Clin Chim Acta 1971;;31:87-96.
13 +
Cattin P:  Note on the estimation of the squared cross-validated multiple correlation of a regression model . Psychol Bull 1980;;87:63-65.
14 +
Maisels M:  Bilirubin . Pediatr Clin North Am 1972;;19:447-501.
15 +
Kierney C, Ainbender E, Brown J, et al:  Comparison of measured and calculated serum bilirubin binding capacity (BBC): A danger exposed . Pediatr Res 1977;;11:536.
16 +
Cashore WJ, Horwich A, Karotkin EH, et al:  Influence of gestational age and clinical status on bilirubin-binding capacity in newborn infants: Sephadex G-25 gel filtration technique . Am J Dis Child 1977;;131:898-901.
17 +
Cashore W:  Free bilirubin concentrations and bilirubin-binding affinity in term and preterm infants . J Pediatr 1980;;96:521-527.

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