Persistent Reactivity of Patent Ductus With a Review of the Mechanism of Spontaneous Closure FREE

DAVID Z. FRIEDBERG, MD; RANJIT S. RAJPAL, MD; S. BERT LITWIN, MD; JOSEPH ZONDLO, MD

Am J Dis Child. 1981;135(5):472-473. doi:10.1001/archpedi.1981.02130290068022.

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ABSTRACT

ABSTRACT | REFERENCES

The ductus arteriosus is reactive to a number of chemical stimuli. These include arterial oxygen tension, catecholamines, kinins, and prostaglandins. Prostaglandin E has been used to maintain the patency of the ductus arteriosus in infants with certain forms of congenital heart disease. Similarly, prostaglandin inhibitors are useful as medical treatment to induce spontaneous closure of the ductus arteriosus in premature infants. We report the persistence of this reactivity of a ductus arteriosus in a 3.5-year-old child, a phenomenon not yet reported in this age group.

Report of a Case.—The patient was a 3.5-year-old twin. The patient was asymptomatic and her twin was unaffected. On physical examination the heart rate was 142 beats per minute, and the blood pressure was 100/60 mm Hg in the right arm. The apical impulse was located at the left fifth intercostal space in the mediclavicular line. There was a prominent thrill in the second

REFERENCES

ABSTRACT | REFERENCES

Moss AJ, Emmanoulides GC, Duffie ER Jr: Closure of the ductus arteriosus in the newborn infant . Pediatrics 1963;;32:25-30.

Eldridge FL, Hultgren HN: The physiological closure of the ductus arteriosus in the newborn infant . J Clin Invest 1955;;34:987-996.

Mitchell SC: The ductus arteriosus in the neonatal period . J Pediatr 1957;;51:12-17.

Jager BV, Wollerman OJ Jr: An anatomical study of the closure of the ductus arteriosus . Am J Pathol 1942;;18:595-613.

Moss AJ, Emmanouilides GC, Adams FH, et al: Response of ductus arteriosus and pulmonary and systemic arterial pressure to changes in oxygen environment in newborn infants . Pediatrics 1964;;33:937-944.

Born GVR, Dawes GS, Mott JC, et al: The constriction of the ductus arteriosus caused by oxygen and by asphyxia in newborn lambs . J Physiol 1956;;132:304-342.

Kovalicik V: The response of isolated ductus arteriosus to oxygen and anoxia . J Physiol 1963;;169:185-197.

Boreus LO, Malmfors T, McMurphy DM, et al: Demonstration of adrenergic receptor function and innervation in the ductus arteriosus of the human fetus . Acta Physiol Scand 1969;;77:316-321.

Coceani F, Olley PM: The response of the ductus arteriosus to prostaglandins . Can J Physiol Pharmacol 1973;;51:220-225.

Olley PM, Coceani F, Bodach E: E type prostaglandins: A new emergency therapy for certain cyanotic congenital heart malformations . Circulation 1976;;53:728-731.

Rudolph AM, Heyman MA: Medical treatment of the ductus arteriosus . Hosp Pract 1977;;12:57-65.

Mark H, Young D: Spontaneous closure of the ductus arteriosus in a young adult . N Engl J Med 1963;;69:416-418.

Benn J: Prognosis of patent ductus arteriosus . Br Heart J 1947;;9:283-291.

Bishop RC: Delayed closure of ductus arteriosus . Am Heart J 1952;;44:639-644.

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