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May 1981, Vol 135, No. 5 >
Article | May 1981

Predicting Acute vs Chronic Childhood Idiopathic Thrombocytopenic Purpura FREE

Russell H. Tomar, MD; Marie J. Stuart, MB, BS
[+] Author Affiliations

Reprint requests to Department of Pathology, Division of Clinical Pathology, State University of New York Upstate Medical Center, 750 E Adams St, Syracuse, NY 13210 (Dr Tomar).


Am J Dis Child. 1981;135(5):446-449. doi:10.1001/archpedi.1981.02130290044016.
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• We studied 12 children with idiopathic thrombocytopenic purpura (ITP) to determine if selected immune measurements could prospectively distinguish chronic ITP from acute ITP. Immunologic assessment included immunoglobulin levels, T- and B-cell enumeration, in vitro lymphocyte stimulation by phytohemagglutinin, and a screen for autoantibodies. The most consistent difference observed was that unstimulated lymphocytes in chronic ITP had an increased basal rate of thymidine incorporation. The same assays were performed on eight other children in whom the diagnosis of chronic ITP already had been established. A similar abnormality was found in this group. Study of lymphocyte proliferation in patients with ITP appears useful in predicting the course of the disease.

(Am J Dis Child 1981;135:446-449)

REFERENCES

1 +
Lusher JM, Zuelzer WW:  Idiopathic thrombocytopenic purpura in childhood . J Pediatr 1966;;68:971-979.
2 +
Lusher JM, Iyer R:  Idiopathic thrombocytopenic purpura in children . Semin Thromb Hemostas 1977;;3:175-199.
3 +
Clancy RL, Muller HK, Ward HA:  Immunodeficiency and grouping with thyrogastric autoimmune disease in patients with chronic idiopathic thrombocytopenic purpura . Aust NZ J Med 1974;;4:243-246.
4 +
Stuart MJ, Tomar RH, Miller ML, et al:  Chronic idiopathic thrombocytopenia purpura: A familial immunodeficiency syndrome? JAMA 1978;;239:939-942.
5 +
Bach JF:  Evaluation of T-cells and thymic serum factors in man using the rosette technique . Transplant Rev 1973;;16:196-217.
6 +
Bianco C, Patrick R, Nussenzweig V:  A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes: I. Separation and characterization . J Exp Med 1970;;132:702-720.
7 +
Oppenheim JJ, Schecter B:  Lymphocyte transformation , in Rose NR, Friedman H (eds): Manual of Clinical Immunology . Washington, DC, American Society for Microbiology, 1976;, pp 81-94.
8 +
Steel RGD, Torrie JH: Principles and Procedures of Statistics . New York, McGraw-Hill Book Co, 1960;, pp 109-110.
9 +
Lightsey AL, Koenig HM, McMillan R, et al:  Platelet-associated immunoglobulin G in childhood idiopathic thrombocytopenic purpura . J Pediatr 1979;;94:201-204.

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References

1 +
Lusher JM, Zuelzer WW:  Idiopathic thrombocytopenic purpura in childhood . J Pediatr 1966;;68:971-979.
2 +
Lusher JM, Iyer R:  Idiopathic thrombocytopenic purpura in children . Semin Thromb Hemostas 1977;;3:175-199.
3 +
Clancy RL, Muller HK, Ward HA:  Immunodeficiency and grouping with thyrogastric autoimmune disease in patients with chronic idiopathic thrombocytopenic purpura . Aust NZ J Med 1974;;4:243-246.
4 +
Stuart MJ, Tomar RH, Miller ML, et al:  Chronic idiopathic thrombocytopenia purpura: A familial immunodeficiency syndrome? JAMA 1978;;239:939-942.
5 +
Bach JF:  Evaluation of T-cells and thymic serum factors in man using the rosette technique . Transplant Rev 1973;;16:196-217.
6 +
Bianco C, Patrick R, Nussenzweig V:  A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes: I. Separation and characterization . J Exp Med 1970;;132:702-720.
7 +
Oppenheim JJ, Schecter B:  Lymphocyte transformation , in Rose NR, Friedman H (eds): Manual of Clinical Immunology . Washington, DC, American Society for Microbiology, 1976;, pp 81-94.
8 +
Steel RGD, Torrie JH: Principles and Procedures of Statistics . New York, McGraw-Hill Book Co, 1960;, pp 109-110.
9 +
Lightsey AL, Koenig HM, McMillan R, et al:  Platelet-associated immunoglobulin G in childhood idiopathic thrombocytopenic purpura . J Pediatr 1979;;94:201-204.

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