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Systolic Time Interval in Infants and Children With Primary Hypothyroidism

OSAMU NOSE, MD; ICHIRO MAKI, MD; TOKUZO HARADA, MD; HAYAKUJI YABUUCHI, MD
Am J Dis Child. 1981;135(4):385. doi:10.1001/archpedi.1981.02130280075033.
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To the Editor.—The article (by Hayford et al) entitled "Cardiac Function in Primary Hypothyroidism" (Journal 1980;134:556-559) was of interest to us. However, the reported results are not consistent with ours. We have also examined systolic time intervals (STIs): left ventricular ejection time (ET), pre-ejection period (PEP), and PEP/ET by using standard echocardiography (according to the methods of Hirschfeld) in nine hypothyroid children (seven were younger than 1 year, and two were 1 and 5 years of age, respectively), three hyperthyroid (age, 10 to 14 years), and 45 normal children (18 were younger than 1 year of age, ten were 1 to 5 years of age, nine were 10 to 15 years of age). Prolongation of PEP/ET was seen in hypothyroid children and its shortening was noted in hyperthyroid children when compared with normal infants and children of the same age. Moreover, many serial studies of systolic time intervals in

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