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April 1981, Vol 135, No. 4 >
Article | April 1981

Effect on Growth in Pemoline-Treated Children With Attention Deficit Disorder FREE

Nadav Friedmann, PhD, MD; John Thomas; Raymond Carr, PhD; Joycelyn Elders, MD; Irving Ringdahl, MD; Alex Roche, MD, PhD
[+] Author Affiliations

Reprint requests to Abbott Laboratories, North Chicago, IL 60064 (Dr Friedmann).


Am J Dis Child. 1981;135(4):329-332. doi:10.1001/archpedi.1981.02130280019007.
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References
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• The growth of 22 children with attention deficit disorder (ADD) was monitored longitudinally for up to four years. Each child received at least one year of continuous, successful pemoline (Cylert) therapy, after which drug "vacations" were allowed. The effective dosage of pemoline ranged from 56 to 150 mg/day during the first year of treatment. Stature and weight measurements at six-month intervals were matched to those of paired "normal" children from the Fels Longitudinal Study. Significant deficits were observed for mean weight change at six and 12 months after baseline, and for mean stature change at 12 and 18 months after baseline. However, all subsequent six-month results up to four years did not differ significantly between the two groups. These results show a temporary retardation in the rate of growth in weight and stature with later catch-up growth in children treated with pemoline.

(Am J Dis Child 1981;135:329-332)

REFERENCES

1 +
The Committee on Nomenclature and Statistics: Diagnostic and Statistical Manual of Mental Disorders , ed 2. Washington, DC, American Psychiatric Association, 1968;, p 50.
2 +
Greenhill LL, Puig-Antich J, Sassin J, et al:  Hormone and growth responses in hyperkinetic children on stimulant medication . Psychopharmacol Bull 1977;;13:33-36.
3 +
Safer D, Allen R, Barr E:  Depression of growth in hyperactive children on stimulant drugs . N Engl J Med 1972;;287:217-220.
4 +
Safer DJ, Allen RP:  Factors influencing the suppressant effects of two stimulant drugs on the growth of hyperactive children . Pediatrics 1973;;51:660-667.
5 +
Weiss G, Kruger E, Danielson U, et al:  Effect of long-term treatment of hyperactive children with methylphenidate . Can Med Assoc J 1975;;112:159-165.
6 +
Conners CK, Taylor E, Meo G, et al:  Magnesium pemoline and dextroamphetamine: A controlled study in children with minimal brain dysfunction . Psychopharmacologia 1972;;26:321-336.
7 +
Roche AF, Lipman RS, Overall JE, et al:  The effects of stimulant medication on the growth of hyperkinetic children . J Pediatr 1979;;63:847-850.
8 +
Mattes J, Gittleman R: The effects of methylphenidate on growth. Read before the 132nd annual meeting of the American Psychiatric Association, Chicago, May 16, 1979.
9 +
Dickinson LC, Lee J, Ringdahl IC, et al:  Impaired growth in hyperkinetic children receiving pemoline . J Pediatr 1979;;94:538-541.
10 +
Conners CK:  A teacher rating scale for use in drug studies with children . Am J Psychiatry 1969;;126:884-888.
11 +
Conners CK:  Symptom patterns in hyperkinetic, neurotic, and normal children . Child Dev 1970;;41:667-682.
12 +
Roche AF, Wainer H, Thissen D: Skeletal Maturity: The Knee Joint as a Biological Indicator . New York, Plenum Medical Book Co, 1975;, pp 1-374.
13 +
Garn SM, French Y: Magnitude of Secular Trend in the Fels Population: Stature, Weight . Yellow Springs, Ohio, Fels Research Institute, 1967;.
14 +
Hamill PVV, Drizd TA, Johnson CL, et al: NCHS Growth Curves for Children: Birth-18 Years . National Health Survey, series 11, No. (165) . DHEW publication (PHS) 78-1650, US Dept of Health, Education, and Welfare, 1977;, pp 1-74.
15 +
Hamill PVV, Drizd TA, Johnson CL, et al:  Physical growth: National Center for Health Statistics percentiles . Am J Clin Nutr 1979;;32:607-629.
16 +
Cylert (Pemoline) Drug Monograph . North Chicago, Ill, Abbott Laboratories Pharmaceutical Products Division, 1975;.
17 +
Page JG, Bernstein JE, Janicki RS, et al:  A multi-clinic trial of pemoline in childhood hyperkinesis , in Conners CK (ed): Clinical Use of Stimulant Drugs in Children . Amsterdam, Excerpta Medica, 1974;, pp 98-124.
18 +
Kilgore BS, Dickinson LC, Burnett CR, et al:  Alterations in cartilage metabolism by neuro-stimulant drugs . J Pediatr 1979;;94:542-545.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
The Committee on Nomenclature and Statistics: Diagnostic and Statistical Manual of Mental Disorders , ed 2. Washington, DC, American Psychiatric Association, 1968;, p 50.
2 +
Greenhill LL, Puig-Antich J, Sassin J, et al:  Hormone and growth responses in hyperkinetic children on stimulant medication . Psychopharmacol Bull 1977;;13:33-36.
3 +
Safer D, Allen R, Barr E:  Depression of growth in hyperactive children on stimulant drugs . N Engl J Med 1972;;287:217-220.
4 +
Safer DJ, Allen RP:  Factors influencing the suppressant effects of two stimulant drugs on the growth of hyperactive children . Pediatrics 1973;;51:660-667.
5 +
Weiss G, Kruger E, Danielson U, et al:  Effect of long-term treatment of hyperactive children with methylphenidate . Can Med Assoc J 1975;;112:159-165.
6 +
Conners CK, Taylor E, Meo G, et al:  Magnesium pemoline and dextroamphetamine: A controlled study in children with minimal brain dysfunction . Psychopharmacologia 1972;;26:321-336.
7 +
Roche AF, Lipman RS, Overall JE, et al:  The effects of stimulant medication on the growth of hyperkinetic children . J Pediatr 1979;;63:847-850.
8 +
Mattes J, Gittleman R: The effects of methylphenidate on growth. Read before the 132nd annual meeting of the American Psychiatric Association, Chicago, May 16, 1979.
9 +
Dickinson LC, Lee J, Ringdahl IC, et al:  Impaired growth in hyperkinetic children receiving pemoline . J Pediatr 1979;;94:538-541.
10 +
Conners CK:  A teacher rating scale for use in drug studies with children . Am J Psychiatry 1969;;126:884-888.
11 +
Conners CK:  Symptom patterns in hyperkinetic, neurotic, and normal children . Child Dev 1970;;41:667-682.
12 +
Roche AF, Wainer H, Thissen D: Skeletal Maturity: The Knee Joint as a Biological Indicator . New York, Plenum Medical Book Co, 1975;, pp 1-374.
13 +
Garn SM, French Y: Magnitude of Secular Trend in the Fels Population: Stature, Weight . Yellow Springs, Ohio, Fels Research Institute, 1967;.
14 +
Hamill PVV, Drizd TA, Johnson CL, et al: NCHS Growth Curves for Children: Birth-18 Years . National Health Survey, series 11, No. (165) . DHEW publication (PHS) 78-1650, US Dept of Health, Education, and Welfare, 1977;, pp 1-74.
15 +
Hamill PVV, Drizd TA, Johnson CL, et al:  Physical growth: National Center for Health Statistics percentiles . Am J Clin Nutr 1979;;32:607-629.
16 +
Cylert (Pemoline) Drug Monograph . North Chicago, Ill, Abbott Laboratories Pharmaceutical Products Division, 1975;.
17 +
Page JG, Bernstein JE, Janicki RS, et al:  A multi-clinic trial of pemoline in childhood hyperkinesis , in Conners CK (ed): Clinical Use of Stimulant Drugs in Children . Amsterdam, Excerpta Medica, 1974;, pp 98-124.
18 +
Kilgore BS, Dickinson LC, Burnett CR, et al:  Alterations in cartilage metabolism by neuro-stimulant drugs . J Pediatr 1979;;94:542-545.

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