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March 1981, Vol 135, No. 3 >
Article | March 1981

Interaction of Minoxidil and Captopril in the Treatment of Refractory Hypertension FREE

James R. Matson, MD; Laurence H. Norby, MD; Jean E. Robillard, MD
[+] Author Affiliations

Reprints not available.


Am J Dis Child. 1981;135(3):256-258. doi:10.1001/archpedi.1981.02130270048016.
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• A case of severe hypertension resistant to multiple drug therapy was controlled with minoxidil, captopril, and propranolol hydrochloride after treatment with these drugs alone or in other combinations had failed. Hyperreninemic hypoaldosteronism with hyperkalemia and acidosis developed after captopril administration was started.

(Am J Dis Child 1981;135:256-258)

REFERENCES

1 +
Pettinger WA, Mitchell HC:  Minoxidil: An alternative to nephrectomy for refractory hypertension . N Engl J Med 289:167-173, 1973;.
2 +
Oka M, Makela M:  Minoxidil in severe hypertension . Acta Med Scand 203:43-47, 1978;.
3 +
Harris DN, Heran CL, Goldenberg HJ, et al:  Effects of SQ 14,225, an orally active inhibitor of angiotensin-converting enzyme on blood pressure, heart rate and plasma renin activity of conscious normotensive dogs . Eur J Pharmacol 51:345-349, 1978;.
4 +
Gavras H, Brunner HR, Turini GA, et al:  Antihypertensive effect of the oral angiotensin converting-enzyme inhibitor SQ 14,225 in man . N Engl J Med 298:991-995, 1978;.
5 +
Bennett WM:  Pericardial effusions associated with minoxidil . Lancet 2:1356, 1977;.
6 +
DuCharme DW, Freyburger WA, Graham BE, et al:  Pharmacologic properties of minoxidil: A new hypotensive agent . J Pharmacol Exp Ther 184:662-670, 1973;.
7 +
O'Malley K, Velasco M, Wells J, et al:  Control plasma renin activity and changes in sympathetic tone as determinants of minoxidil-induced increase in plasma renin activity . J Clin Invest 55:230-234, 1975;.
8 +
Pettinger WA, Mitchell HC:  Renin release, saralasin and the vasodilator-β-blocker drug interaction in man . N Engl J Med 292:1214-1217, 1975;.
9 +
Pettinger WA, Keeton K:  Altered renin release and propranolol potentiation of vasodilatory drug hypotension . J Clin Invest 55:236-243, 1975;.
10 +
Vollmer RR, Boccagno JA, Harris DN, et al:  Hypotension induced by inhibition of angiotension-converting enzyme in pentobarbital-anesthetized dogs . Eur J Pharmacol 51:39-45, 1978;.
11 +
Brenner BM, Rector FG (eds): The Kidney . Philadelphia, WB Saunders Co, 1976;, p 1492.
12 +
Gerstein AR, Kleeman CR, Gold EM, et al:  Aldosterone deficiency in chronic renal failure . Nephron 5:90-105, 1968;.
13 +
Brunner HR, Gavras H, Waeber B, et al:  Oral angiotensin-converting enzyme inhibitor in long-term treatment of hypertensive patients . Ann Intern Med 90:19-23, 1979;.
14 +
Oberfield SE, Case DB, Levine LS, et al:  Use of the oral angiotensin I converting enzyme inhibitor (captopril) in childhood malignant hypertension . J Pediatr 95:641-644, 1979;.
15 +
Edelman CM (ed): Pediatric Kidney Disease . Boston, Little Brown & Co, 1978;, p 480.
16 +
 Captopril for hypertension . Med Lett Drugs Ther 22:39-40, 1980;.

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References

1 +
Pettinger WA, Mitchell HC:  Minoxidil: An alternative to nephrectomy for refractory hypertension . N Engl J Med 289:167-173, 1973;.
2 +
Oka M, Makela M:  Minoxidil in severe hypertension . Acta Med Scand 203:43-47, 1978;.
3 +
Harris DN, Heran CL, Goldenberg HJ, et al:  Effects of SQ 14,225, an orally active inhibitor of angiotensin-converting enzyme on blood pressure, heart rate and plasma renin activity of conscious normotensive dogs . Eur J Pharmacol 51:345-349, 1978;.
4 +
Gavras H, Brunner HR, Turini GA, et al:  Antihypertensive effect of the oral angiotensin converting-enzyme inhibitor SQ 14,225 in man . N Engl J Med 298:991-995, 1978;.
5 +
Bennett WM:  Pericardial effusions associated with minoxidil . Lancet 2:1356, 1977;.
6 +
DuCharme DW, Freyburger WA, Graham BE, et al:  Pharmacologic properties of minoxidil: A new hypotensive agent . J Pharmacol Exp Ther 184:662-670, 1973;.
7 +
O'Malley K, Velasco M, Wells J, et al:  Control plasma renin activity and changes in sympathetic tone as determinants of minoxidil-induced increase in plasma renin activity . J Clin Invest 55:230-234, 1975;.
8 +
Pettinger WA, Mitchell HC:  Renin release, saralasin and the vasodilator-β-blocker drug interaction in man . N Engl J Med 292:1214-1217, 1975;.
9 +
Pettinger WA, Keeton K:  Altered renin release and propranolol potentiation of vasodilatory drug hypotension . J Clin Invest 55:236-243, 1975;.
10 +
Vollmer RR, Boccagno JA, Harris DN, et al:  Hypotension induced by inhibition of angiotension-converting enzyme in pentobarbital-anesthetized dogs . Eur J Pharmacol 51:39-45, 1978;.
11 +
Brenner BM, Rector FG (eds): The Kidney . Philadelphia, WB Saunders Co, 1976;, p 1492.
12 +
Gerstein AR, Kleeman CR, Gold EM, et al:  Aldosterone deficiency in chronic renal failure . Nephron 5:90-105, 1968;.
13 +
Brunner HR, Gavras H, Waeber B, et al:  Oral angiotensin-converting enzyme inhibitor in long-term treatment of hypertensive patients . Ann Intern Med 90:19-23, 1979;.
14 +
Oberfield SE, Case DB, Levine LS, et al:  Use of the oral angiotensin I converting enzyme inhibitor (captopril) in childhood malignant hypertension . J Pediatr 95:641-644, 1979;.
15 +
Edelman CM (ed): Pediatric Kidney Disease . Boston, Little Brown & Co, 1978;, p 480.
16 +
 Captopril for hypertension . Med Lett Drugs Ther 22:39-40, 1980;.

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