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March 1981, Vol 135, No. 3 >
Article | March 1981

Dose Response of Subcutaneous Terbutaline and Epinephrine in Children With Acute Asthma FREE

F. Estelle R. Simons, MD; John D. Gillies, MB, ChB
[+] Author Affiliations

Reprint requests to Department of Pediatrics, University of Manitoba, 685 Bannatyne Ave, Winnipeg, Manitoba, Canada R3E 0W1 (Dr Simons).


Am J Dis Child. 1981;135(3):214-217. doi:10.1001/archpedi.1981.02130270006004.
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• In a double-blind dose response study in 26 children, 3, 6, or 12 μg/kg of terbutaline sulfate was compared with 10 μg/kg of epinephrine administered subcutaneously. In the first hour after subtion, all doses of terbutaline and epinephrine resulted in improvement in mean clinical score, mean forced vital capacity, mean forced expiratory volume in the first second, and mean forced expiratory flow from 25% to 75% of vital capacity. Terbutaline was not significantly more effective than epinephrine. However, while adverse effects following terbutaline were clinically imperceptible, epinephrine produced unpleasant headache and excitement in a few patients. Terbutaline did not change mean PaO2 or PaCO2 significantly in a subgroup of patients. The 12 μg/kg dose of terbutaline was superior to 3 or 6 μg/kg in relieving obstruction to airflow measured at the midportion of the vital capacity. This dose caused tremor in some children, but the tremor was not apparent to patients or their parents.

(Am J Dis Child 1981;135:214-217)

REFERENCES

1 +
Davis WJ, Pang LM, Chernack WJ, et al:  Terbutaline in the treatment of acute asthma in childhood . Chest 1977;;72:614-617.
2 +
Sly RM, Badiei B, Faciane J:  Comparison of subcutaneous terbutaline with epinephrine in the treatment of asthma in children . J Allergy Clin Immunol 1977;;59:128-135.
3 +
Hansing B, Kjellman B:  The effect of a new sympathomimetic β-receptor stimulating agent, terbutaline, given subcutaneously to asthmatic children . Acta Allergol 1972;;27:130-136.
4 +
Kusoffsky E, Kraepelien S:  Terbutaline subcutaneously injected for the treatment of bronchial asthma in children . Acta Allergol 1974;;29:256-260.
5 +
Koivikko A:  A comparison of the effects of subcutaneous orciprenaline, salbutamol and terbutaline in asthmatic children . Ann Clin Res 1974;;6:99-104.
6 +
Shapiro GG, Simons FE, Pierson WE, et al:  The management of status asthmaticus in children , in Smith CA (ed): The Critically Ill Child: Diagnosis and Management . Philadelphia, WB Saunders Co, 1977;, pp 178-193.
7 +
Lindquist EF: Design and Analysis of Experiments . Boston, Houghton Mifflin Co, 1956;, p 266.
8 +
Pang LM, Rodriguez-Martinez F, Davis WJ, et al:  Terbutaline in the treatment of status asthmaticus . Chest 1977;; 72:469-473.

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References

1 +
Davis WJ, Pang LM, Chernack WJ, et al:  Terbutaline in the treatment of acute asthma in childhood . Chest 1977;;72:614-617.
2 +
Sly RM, Badiei B, Faciane J:  Comparison of subcutaneous terbutaline with epinephrine in the treatment of asthma in children . J Allergy Clin Immunol 1977;;59:128-135.
3 +
Hansing B, Kjellman B:  The effect of a new sympathomimetic β-receptor stimulating agent, terbutaline, given subcutaneously to asthmatic children . Acta Allergol 1972;;27:130-136.
4 +
Kusoffsky E, Kraepelien S:  Terbutaline subcutaneously injected for the treatment of bronchial asthma in children . Acta Allergol 1974;;29:256-260.
5 +
Koivikko A:  A comparison of the effects of subcutaneous orciprenaline, salbutamol and terbutaline in asthmatic children . Ann Clin Res 1974;;6:99-104.
6 +
Shapiro GG, Simons FE, Pierson WE, et al:  The management of status asthmaticus in children , in Smith CA (ed): The Critically Ill Child: Diagnosis and Management . Philadelphia, WB Saunders Co, 1977;, pp 178-193.
7 +
Lindquist EF: Design and Analysis of Experiments . Boston, Houghton Mifflin Co, 1956;, p 266.
8 +
Pang LM, Rodriguez-Martinez F, Davis WJ, et al:  Terbutaline in the treatment of status asthmaticus . Chest 1977;; 72:469-473.

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