0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Screening Newborns for Sickle Cell Anemia-Reply

PETER T. ROWLEY, MD
Am J Dis Child. 1980;134(12):1181-1182. doi:10.1001/archpedi.1980.02130240060030.
Text Size: A A A
Published online

In Reply.—Dr Smith would have preferred that our differential diagnosis of the proposita deal more extensively with β+ vs β° thalassemia and the difference in their clinical presentation. We point out that the differential diagnostic process for newborns differs from that appropriate for the symptomatic child in that there is no clinical history. The differential diagnosis is that of a hemoglobin composition, not that of a clinical course. The hemoglobin composition of the proposita described (principally Hb S without Hb A) automatically excludes sickle-β+ thalassemia, and therefore it was not discussed. As explained in the third paragraph of the "Comment" section, it is sickle-β thalassemia that must be distinguished from sickle cell anemia because in both there is no synthesis of Hb A.

Drs Grover and Wethers claim that, in the family described, "neither confirmatory testing nor family studies were obtained appropriately." Regarding confirmatory testing, as the article states,

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();