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Urine C-peptide, β-Cell Function, and Insulin Requirement

Elizabeth B. Rappaport, MD; Robert A. Ulstrom, MD; Donnell D. Etzwiler, MD; Daniel Fife, MD; Bo E. Hedlund, PhD; Michael W. Steffes, MD, PhD
Am J Dis Child. 1980;134(12):1129-1133. doi:10.1001/archpedi.1980.02130240013006.
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• Urinary C-peptide excretion was investigated as a method for monitoring β-cell function in diabetic patients and for studying the contribution of endogenous insulin production to diabetic control. Control subjects had variations in serum and urine C-peptide immunoreactivity that correlated with basal and meal-related insulin secretion. In a group of well-controlled juvenile diabetic patients, those receiving high doses of insulin had low or negligible C-peptide excretion, whereas most patients with low exogenous insulin requirements had near-normal urinary C-peptide excretion. Patients treated for diabetic ketoacidosis had recovery of β-cell function as measured by C-peptide immunoreactivity in serial urine specimens. Thus, measurement of urinary C-peptide excretion is a simple technique that may be useful in assessing endogenous insulin production in juvenile diabetic patients.

(Am J Dis Child 134:1129-1133, 1980)


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