We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Asymptomatic Familial Elevation of Serum Alkaline Phosphatase Levels

Am J Dis Child. 1980;134(11):1094-1095. doi:10.1001/archpedi.1980.02130230072022.
Text Size: A A A
Published online


Asymptomatic elevation of serum alkaline phosphatase levels has been reported recently in one family. An autosomal dominant inheritance was suggested by father-son transmission.1 Both liver and bone isoenzyme levels were elevated. We describe another family that had elevations of serum alkaline phosphatase levels without apparent disease. In this family, the heat labile fraction (representing the bone isoenzyme level) was greater than 90% in all affected individuals.

Report of a Case.—An 11-year-old asymptomatic girl was found to have an elevated serum alkaline phoshatase level after the incidental discovery of an increased level in her mother. Extensive investigations failed to reveal a cause for the elevated level in the mother. Results of a physical examination of the daughter were entirely normal. Results of laboratory studies, including complete blood cell count, urinalysis, and serum chemistries, were normal except for a fasting serum alkaline phosphatase level of 664 IU/L (normal, 40 to 110


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.