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October 1980, Vol 134, No. 10 >
Article | October 1980

Simultaneous Microangiopathic Hemolytic Anemia, Thrombocytopenia, and Acute Nephropathy in Mother and Child FREE

RICHARD L. SIEGLER, MD; ROBERT E. BOND, MD
Am J Dis Child. 1980;134(10):991-992. doi:10.1001/archpedi.1980.02130220067021.
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Microangiopathic hemolytic anemia, thrombocytopenia, and acute nephropathy are hallmarks of the hemolytic-uremic syndrome (HUS).1 Though there have been reports of HUS occurring in families,2-6 we are unaware of previous reports of microangiopathic hemolytic anemia, thrombocytopenia, and renal failure occurring simultaneously in parent and child.

Report of Cases.—Case 1.—A 31-year-old woman had been well until diarrhea and abdominal pain developed. Three days later, her stools became bloody, and she was admitted to the hospital.

Her initial hematocrit reading was 52%, and a few schistocytes were seen on blood smear. Platelets appeared adequate in number. The urine was concentrated, had ketones, but was otherwise normal. Her BUN and serum creatinine concentrations were 5.0 and 0.9 mg/dL, respectively. On the third hospital day, she became febrile, numerous purpuric lesions developed, and she became confused and lethargic. The platelet count fell to 40,000/cu mm, and the peripheral smear showed increased

REFERENCES

1 +
Kaplan BS, Thomson PD, de Chadarevian JP:  The hemolytic uremic syndrome . Pediatr Clin North Am 23:761-777, 1976;.
2 +
Kaplan BS, Chesney RW, Drummond KN:  Hemolytic uremic syndrome in families . N Engl J Med 292:1090-1093, 1975;.
Link to Article
3 +
Farr MJ, Roberts S, Morley AR, et al:  The hemolytic uremic syndrome: A family study . Q J Med 44:161-188, 1975;.
4 +
Karlesberg RP, Laecher JW, Bartecchi CE:  Adult hemolytic-uremic syndrome . Arch Intern Med 137:1155-1157, 1977;.
Link to Article
5 +
Hogewind BL, de la Riviere GB:  A family with the hemolytic-uremic syndrome in childhood and in the postpartum period, abstracted . Kidney Int 11:222, 1977;.
6 +
Blattler W, Wegmann W, Herold H, et al:  Familiares hamolytisch-uramisches syndrom . Schweiz Med Wochenschr 105:1773-1774, 1975;.
7 +
Dolislager D, Tune B:  The hemolytic-uremic syndrome . Am J Dis Child 132:55-58, 1978;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Kaplan BS, Thomson PD, de Chadarevian JP:  The hemolytic uremic syndrome . Pediatr Clin North Am 23:761-777, 1976;.
2 +
Kaplan BS, Chesney RW, Drummond KN:  Hemolytic uremic syndrome in families . N Engl J Med 292:1090-1093, 1975;.
Link to Article
3 +
Farr MJ, Roberts S, Morley AR, et al:  The hemolytic uremic syndrome: A family study . Q J Med 44:161-188, 1975;.
4 +
Karlesberg RP, Laecher JW, Bartecchi CE:  Adult hemolytic-uremic syndrome . Arch Intern Med 137:1155-1157, 1977;.
Link to Article
5 +
Hogewind BL, de la Riviere GB:  A family with the hemolytic-uremic syndrome in childhood and in the postpartum period, abstracted . Kidney Int 11:222, 1977;.
6 +
Blattler W, Wegmann W, Herold H, et al:  Familiares hamolytisch-uramisches syndrom . Schweiz Med Wochenschr 105:1773-1774, 1975;.
7 +
Dolislager D, Tune B:  The hemolytic-uremic syndrome . Am J Dis Child 132:55-58, 1978;.

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