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TAR Syndrome: Dorsal Pedal Edema and Excessi ve Perspiration

Am J Dis Child. 1980;134(9):895-896. doi:10.1001/archpedi.1980.02130210075023.
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The thrombocytopenia absent radius (TAR) syndrome is inherited in an autosomal-recessive manner and consists of thrombocytopenia during the neonatal period, a leukemoid reaction during the first year of life, eosinophilia, anemia, bilateral absence of the radius, radial deviation of the hand, abnormalities of the ulna and humerus, other skeletal anomalies, micrognathia, and congenital heart disease. Bleeding, specifically intracranial bleeding, is potentially the most serious problem.

Report of Cases.—We recently evaluated this syndrome in eight patients and noted two findings that have not been, to our knowledge, previously reported in association with this syndrome: dorsal edema of the feet and excessive perspiration. Two of the patients were brothers and two were first cousins. Six of the eight patients had nonpitting edema of the dorsa of their feet at birth. The duration of the edema varied. In one infant, it was no longer present at 3 months and in another it


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