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Ring Chromosome 15 and Failure to Thrive

Am J Dis Child. 1980;134(8):798-799. doi:10.1001/archpedi.1980.02130200066022.
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Ring chromosomes are rare in man. Friedrich and Nielson1 could not find one ring in the compiled data of the cytogenetic screening of 31,801 consecutive live-born children. Hecht and Vlietinck,2 as well as Zdansky et al,3 claim that the phenotypic and cytogenetic differences among even "identical rings" do not permit an accurate delineation of an identifiable syndrome. On the other hand, certain ring chromosome syndromes (ring 1, 6, 9,13, 15, 21, and 22) appear already in textbooks4 as separate clinical entities. To solve the controversy, more case reports seem warranted. Therefore, we discuss an infant with ring 15.

Report of a Case.—This girl was a product of the second pregnancy for her mother, who was 161 cm tall and 27 years of age at that time. The father was 168 cm tall and 35 years of age. Illness, exposure to drugs, and roentgenograms during the pregnancy were


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