Maternal chickenpox may result in one of the following two major clinical syndromes: early onset postnatal chickenpox or intrauterine infection.1-2 Infection in the susceptible female early in gestation may rarely lead to severely affected infants who may display multiple congenital anomalies, as described in several similar case reports.3-5
Dermatomal localization, the sine qua non of shingles, has been a prominent feature of some of the case reports of the severely affected neonates as well as of a few cases of isolated disease early in life. This report documents the cases of two infants who had shingles during the first few months of life after intrauterine exposure to varicella-zoster virus.
Materials and Methods.—Standard virological procedures were used for the identification and isolation of varicella-zoster virus. Levels of complement-fixing anti-body to varicella-zoster virus were determined by the methodology described by Brunell and Casey.6 Immunofluorescence antibody was determined