• Cardiac chamber dimensions and myocardial function were studied in 15 children with primary hypothyroidism prior to and after thyroxine therapy. Small pericardial effusions were detected in 11 of 15 subjects before therapy, which resolved in nine of 11 subjects after initiation of thyroxine replacement. There was no association between the severity of the thyroid failure and the presence of effusion, and no evidence of cardiac compromise due to effusions. No significant abnormality in cardiac chamber or myocardial dimensions, systolic time intervals, or indices of myocardial contractility was detected among the hypothyroid children as compared with a normal population. Neither myocardial dimensions nor contractility indices changed significantly on reestablishment of normal thyroxine concentrations with exogenous hormone. These data refute the existence of a myocardiopathy associated with hypothyroidism in children.
(Am J Dis Child 134:556-559, 1980)