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April 1980, Vol 134, No. 4 >
Article | April 1980

Fulminant Neonatal Meningococcemia FREE

Herbert W. Clegg, MD; I. David Todres, MD; Fergus M. B. Moylan, MD; Daniel E. Keim, MD; Daniel C. Shannon, MD
[+] Author Affiliations

Reprint requests to Massachusetts General Hospital, Fruit Street, Boston, MA 02114 (Dr Todres).


Am J Dis Child. 1980;134(4):354-355. doi:10.1001/archpedi.1980.04490010012004.
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Comments

• Neisseria meningitidis is a rare cause of infection in infants younger than 2 months of age, presumably because of transplacental passage of protective maternal antibodies. In most reported cases of meningococcal disease in neonates, a relatively mild clinical course has been observed. A 25-day-old infant survived acute, severe meningococcemia due to group B N meningitidis. This organism should be considered when neonates have signs of septicemia, especially in the presence of cutaneous petechiae and purpura.

(Am J Dis Child 134:354-355, 1980)

REFERENCES

1 +
Klein JO, Marcy SM:  Bacterial infections , in Remington JS, Klein JO (eds): Infectious Diseases of the Fetus and Newborn Infant . Philadelphia, WB Saunders Co, 1976;, p 747.
2 +
Groover RV, Sutherland JM, Landing BH:  Purulent meningitis of newborn infants: Elevenyear experience in the antibiotic era . N Engl J Med 264:1115-1121, 1961;.
3 +
Stiehm ER, Damrosch DS:  Factors in the prognosis of meningococcal infection: Review of 63 cases with emphasis on recognition and management of the severely ill patient . J Pediatr 68:457-467, 1966;.
4 +
Hodes HL:  Endotoxin shock , in Smith CA (ed): The Critically Ill Child , ed 2. Philadelphia, WB Saunders Co, 1977;, pp 25-45.
5 +
Gross S, Melhorn DK:  Exchange transfusion with citrated whole blood for disseminated intravascular coagulation . J Pediatr 78:415-419, 1971;.
6 +
Mauger DC:  Hypokalemia as a consistent feature of fulminant meningococcal septicaemia . Aust Paediatr J 7:84-86, 1971;.
7 +
Stiehm ER, Damrosch DS:  Neonatal meningococcal meningitis: Report of a case acquired in the nursery . J Pediatr 68:654-656, 1966;.
8 +
Sunderland WA, Harris HH, Spence DA, et al:  Meningococcemia in a newborn infant whose mother had meningococcal vaginitis . J Pediatr 81:856, 1972;.
9 +
Jones RN, Slepack J, Eades A:  Fatal neonatal meningococcal meningitis: Association with maternal cervical-vaginal colonization . JAMA 236:2652-2653, 1976;.
10 +
Goldschneider I, Gotschlich EC, Artenstein MS:  Human immunity to the meningococcus: I. The role of humoral antibodies . J Exp Med 129:1307-1326, 1969;.
11 +
Goldschneider I, Gotschlich EC, Artenstein MS:  Human immunity to the meningococcus: II. Development of natural immunity . J Exp Med 129:1327-1348, 1969;.
12 +
Carvalho AD, Giampaglia CM, Kimura H, et al:  Maternal and infant antibody response to meningococcal vaccination in pregnancy . Lancet 2:809-811, 1977;.
13 +
Faur YC, Weisburd MH, Wilson MD:  Isolation of Neisseria meningitidis from the genitourinary tract and anal canal . J Clin Microbiol 2:178-182, 1975;.
14 +
Judson FN, Ehret JM, Eickhoff TC:  Anogenital infection with Neisseria meningitidis in homosexual men . J Infect Dis 137:458-463, 1978;.
15 +
Manginello FP, Pascale JA, Wolfsdorf J:  Neonatal meningococcemia . AJDC 133:651-652, 1979;.

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References

1 +
Klein JO, Marcy SM:  Bacterial infections , in Remington JS, Klein JO (eds): Infectious Diseases of the Fetus and Newborn Infant . Philadelphia, WB Saunders Co, 1976;, p 747.
2 +
Groover RV, Sutherland JM, Landing BH:  Purulent meningitis of newborn infants: Elevenyear experience in the antibiotic era . N Engl J Med 264:1115-1121, 1961;.
3 +
Stiehm ER, Damrosch DS:  Factors in the prognosis of meningococcal infection: Review of 63 cases with emphasis on recognition and management of the severely ill patient . J Pediatr 68:457-467, 1966;.
4 +
Hodes HL:  Endotoxin shock , in Smith CA (ed): The Critically Ill Child , ed 2. Philadelphia, WB Saunders Co, 1977;, pp 25-45.
5 +
Gross S, Melhorn DK:  Exchange transfusion with citrated whole blood for disseminated intravascular coagulation . J Pediatr 78:415-419, 1971;.
6 +
Mauger DC:  Hypokalemia as a consistent feature of fulminant meningococcal septicaemia . Aust Paediatr J 7:84-86, 1971;.
7 +
Stiehm ER, Damrosch DS:  Neonatal meningococcal meningitis: Report of a case acquired in the nursery . J Pediatr 68:654-656, 1966;.
8 +
Sunderland WA, Harris HH, Spence DA, et al:  Meningococcemia in a newborn infant whose mother had meningococcal vaginitis . J Pediatr 81:856, 1972;.
9 +
Jones RN, Slepack J, Eades A:  Fatal neonatal meningococcal meningitis: Association with maternal cervical-vaginal colonization . JAMA 236:2652-2653, 1976;.
10 +
Goldschneider I, Gotschlich EC, Artenstein MS:  Human immunity to the meningococcus: I. The role of humoral antibodies . J Exp Med 129:1307-1326, 1969;.
11 +
Goldschneider I, Gotschlich EC, Artenstein MS:  Human immunity to the meningococcus: II. Development of natural immunity . J Exp Med 129:1327-1348, 1969;.
12 +
Carvalho AD, Giampaglia CM, Kimura H, et al:  Maternal and infant antibody response to meningococcal vaccination in pregnancy . Lancet 2:809-811, 1977;.
13 +
Faur YC, Weisburd MH, Wilson MD:  Isolation of Neisseria meningitidis from the genitourinary tract and anal canal . J Clin Microbiol 2:178-182, 1975;.
14 +
Judson FN, Ehret JM, Eickhoff TC:  Anogenital infection with Neisseria meningitidis in homosexual men . J Infect Dis 137:458-463, 1978;.
15 +
Manginello FP, Pascale JA, Wolfsdorf J:  Neonatal meningococcemia . AJDC 133:651-652, 1979;.

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