Article |

Cimetidine in Pregnancy: Apparent Transient Liver Impairment in the Newborn

Am J Dis Child. 1980;134(1):87-88. doi:10.1001/archpedi.1980.02130130069021.
Text Size: A A A
Published online

Cimetidine, a potent H2 receptor antagonist, recently introduced for the treatment of peptic ulcer and other related disorders, has gained widespread use. Most of the current knowledge of its use and effects is based on adult clinical trials. There is a lack of data on its effects in children and infants and virtually none on the human fetus. Animal studies using radioactive labeled cimetidine at doses of 100 mg/kg indicate that this drug crosses the placental barrier and has thus the potential of producing a systemic effect in utero. Elevated transaminase levels have been reported in adults,1.2 and cholestatic jaundice has been observed in children.3 This report concerns the finding of liver impairment in an infant born to a mother receiving cimetidine in the last trimester of her pregnancy.

Report of a Case.—This male patient was born to a 39-year-old, gravida 4, para 2, still-birth 1 whose


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.