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January 1980, Vol 134, No. 1 >
Article | January 1980

Vasoactive Intestinal Peptide Secreting Tumors of Childhood FREE

Saul J. Kaplan; C. Tate Holbrook, MD; Huey G. McDaniel, MD; William L. Buntain, MD; William M. Crist, MD
[+] Author Affiliations

Reprint requests to The Children's Hospital, 1601 6th Ave South, Birmingham, AL 35233 (Dr Crist).


Am J Dis Child. 1980;134(1):21-24. doi:10.1001/archpedi.1980.02130130013005.
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• A 2-year-old boy with failure to thrive, watery diarrhea, abdominal distention, hypokalemia, metabolic acidosis, and episodes of hypertension and sweating was found to have a calcified right lower quadrant mass. Blood levels of vasoactive intestinal peptide (VIP) and norepinephrine (NE) were elevated. Presurgical management with phenoxybenzamine hydrochloride and metyrosine was associated with an absence of expected postoperative hypotension, and resection of a benign ganglioneuroma resulted in prompt relief of all symptoms and return to normal of VIP and NE levels. Evidence supports the theory that VIP is the substance responsible for the diarrhea that accompanies some neural crest tumors.

(Am J Dis Child 134:21-24, 1980)

REFERENCES

1 +
Sutow W, Vietti T, Fernbach D: Clinical Pediatric Oncology , ed 2. St Louis, CV Mosby Co, 1977;, p 3.
2 +
Scully RE, McNeily BU:  Weekly clinicopathological exercises . N Engl J Med 291:1351-1355, 1974;.
3 +
Bloom SR, Polak JM, Pearse AGE:  Vasoactive intestinal peptide and watery diarrhea syndrome . Lancet 2:14-16, 1973;.
4 +
Sprinkle TJ, Porter AH, Greer M, et al:  An improved method for the determination of homovanillic acid and vanillylmandelic acid by gas chromatography . Clin Chim Act 25:409-411, 1969;.
5 +
Kissinger PT, Riggin RM, Allcorn RL, et al:  Estimation of catecholamines in the urine by high performance liquid chromatography with electrochemical detection . Biochem Med 13:299-306, 1975;.
6 +
Said SI, Faloona GR:  Elevated plasma and tissue levels of vasoactive intestinal peptide in the watery diarrhea syndrome due to pancreatic, bronchogenic and other tumors . N Engl J Med 293:153-160, 1975;.
7 +
Voors AW, Webber LS, Berenson GS:  A consideration of essential hypertension in children . Pract Cardiol 3:29-40, 1977;.
8 +
Hawfield HH, Daisley CW:  A report of a case of a functional adrenal ganglioneuroma . Clin Proc Child Hosp 8:98-105, 1952;.
9 +
Rosenstein BJ, Engelman K:  Diarrhea in a child with a catecholamine secreting ganglioneuroma . J Pediatr 63:217-226, 1963;.
10 +
Verner JV, Morrison AB:  Islet cell tumor and a syndrome of refractory watery diarrhea and hypokalemia . Am J Med 25:374-380, 1958;.
11 +
Verner JV, Morrison AB:  Non-beta islet tumors and the syndrome of watery diarrhoea, hypokalemia and hypochlorhydria . Clin Gastroenterol 3:595-606, 1974;.
12 +
Schwartz CJ, Kimberg DV, Sheerin HE, et al:  Vasoactive intestinal peptide stimulation of adenylate cyclase and active electrolyte secretion in intestinal mucosa . J Clin Invest 54:536-544, 1974;.
13 +
Jansen-Goemans A, Engelhardt J:  Intractable diarrhea in a boy with vasoactive intestinal peptide producing ganglioneuroblastoma . Pediatrics 59:710-716, 1977;.
14 +
Swift PGF, Bloom SR, Harris F:  Watery diarrhea and ganglioneuroma with secretion of vasoactive intestinal peptide . Arch Dis Child 50:896-899, 1975;.
15 +
Udall JN, Singer DB, Huang CTL, et al:  Watery diarrhea and hypokalemia associated with increased plasma vasoactive intestinal peptide in a child . J Pediatr 88:819-821, 1976;.
16 +
Mitchell CH, Sinatra FR, Crast FW, et al:  Intractable watery diarrhea, ganglioneuroblastoma and vasoactive intestinal peptide . J Pediatr 89:593-595, 1976;.
17 +
Leupold D, Rosch U, Zollner E, et al:  Chronische Diarrhoe, Ganglioneurom und vaso-active intestinal Polypeptide (VIP) . Monatsschr Kinderheilkd 125:462-463, 1977;.
18 +
Ricour C, Duhamel JF, Lesec G, et al:  Diarrhee choleriforme dans un cas de ganglioneuroblastome . Arch Fr Pediatr 34:552-555, 1977;.
19 +
Fontaine JL, Giardet JP, Bataille D, et al:  Sympathome et diarrhee par hypersecretion de "Vasoactive Intestinal Peptide" (VIP): A propos d'une nouvelle observation . Arch Fr Pediatr 34:577-578, 1977;.
20 +
Modlin IM, Bloom SR, Barnes A, et al:  Cure of intractable watery diarrhoea by excision of vipoma . Br J Surg 65:234-236, 1978;.
21 +
Taylor AR, Chaljata D, Jones DH, et al:  Adrenal tumor secreting vasoactive intestinal peptide and noradrenalin . Anesthesia 32:1012-1016, 1977;.
22 +
Peterson HD, Collins OD:  Chronic diarrhea and failure to thrive secondary to ganglioneuroma . Arch Surg 95:934-936, 1967;.
23 +
Sabiston DC (ed): David-Christopher Textbook of Surgery , ed 11. Philadelphia, WB Saunders Inc, 1977;, pp 739-790.
24 +
Engelman K, Horwitz D, Jequiet E, et al:  Biochemical and pharmacologic effects of alpha-methyltyrosine in man . J Clin Invest 47:577-594, 1968;.

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References

1 +
Sutow W, Vietti T, Fernbach D: Clinical Pediatric Oncology , ed 2. St Louis, CV Mosby Co, 1977;, p 3.
2 +
Scully RE, McNeily BU:  Weekly clinicopathological exercises . N Engl J Med 291:1351-1355, 1974;.
3 +
Bloom SR, Polak JM, Pearse AGE:  Vasoactive intestinal peptide and watery diarrhea syndrome . Lancet 2:14-16, 1973;.
4 +
Sprinkle TJ, Porter AH, Greer M, et al:  An improved method for the determination of homovanillic acid and vanillylmandelic acid by gas chromatography . Clin Chim Act 25:409-411, 1969;.
5 +
Kissinger PT, Riggin RM, Allcorn RL, et al:  Estimation of catecholamines in the urine by high performance liquid chromatography with electrochemical detection . Biochem Med 13:299-306, 1975;.
6 +
Said SI, Faloona GR:  Elevated plasma and tissue levels of vasoactive intestinal peptide in the watery diarrhea syndrome due to pancreatic, bronchogenic and other tumors . N Engl J Med 293:153-160, 1975;.
7 +
Voors AW, Webber LS, Berenson GS:  A consideration of essential hypertension in children . Pract Cardiol 3:29-40, 1977;.
8 +
Hawfield HH, Daisley CW:  A report of a case of a functional adrenal ganglioneuroma . Clin Proc Child Hosp 8:98-105, 1952;.
9 +
Rosenstein BJ, Engelman K:  Diarrhea in a child with a catecholamine secreting ganglioneuroma . J Pediatr 63:217-226, 1963;.
10 +
Verner JV, Morrison AB:  Islet cell tumor and a syndrome of refractory watery diarrhea and hypokalemia . Am J Med 25:374-380, 1958;.
11 +
Verner JV, Morrison AB:  Non-beta islet tumors and the syndrome of watery diarrhoea, hypokalemia and hypochlorhydria . Clin Gastroenterol 3:595-606, 1974;.
12 +
Schwartz CJ, Kimberg DV, Sheerin HE, et al:  Vasoactive intestinal peptide stimulation of adenylate cyclase and active electrolyte secretion in intestinal mucosa . J Clin Invest 54:536-544, 1974;.
13 +
Jansen-Goemans A, Engelhardt J:  Intractable diarrhea in a boy with vasoactive intestinal peptide producing ganglioneuroblastoma . Pediatrics 59:710-716, 1977;.
14 +
Swift PGF, Bloom SR, Harris F:  Watery diarrhea and ganglioneuroma with secretion of vasoactive intestinal peptide . Arch Dis Child 50:896-899, 1975;.
15 +
Udall JN, Singer DB, Huang CTL, et al:  Watery diarrhea and hypokalemia associated with increased plasma vasoactive intestinal peptide in a child . J Pediatr 88:819-821, 1976;.
16 +
Mitchell CH, Sinatra FR, Crast FW, et al:  Intractable watery diarrhea, ganglioneuroblastoma and vasoactive intestinal peptide . J Pediatr 89:593-595, 1976;.
17 +
Leupold D, Rosch U, Zollner E, et al:  Chronische Diarrhoe, Ganglioneurom und vaso-active intestinal Polypeptide (VIP) . Monatsschr Kinderheilkd 125:462-463, 1977;.
18 +
Ricour C, Duhamel JF, Lesec G, et al:  Diarrhee choleriforme dans un cas de ganglioneuroblastome . Arch Fr Pediatr 34:552-555, 1977;.
19 +
Fontaine JL, Giardet JP, Bataille D, et al:  Sympathome et diarrhee par hypersecretion de "Vasoactive Intestinal Peptide" (VIP): A propos d'une nouvelle observation . Arch Fr Pediatr 34:577-578, 1977;.
20 +
Modlin IM, Bloom SR, Barnes A, et al:  Cure of intractable watery diarrhoea by excision of vipoma . Br J Surg 65:234-236, 1978;.
21 +
Taylor AR, Chaljata D, Jones DH, et al:  Adrenal tumor secreting vasoactive intestinal peptide and noradrenalin . Anesthesia 32:1012-1016, 1977;.
22 +
Peterson HD, Collins OD:  Chronic diarrhea and failure to thrive secondary to ganglioneuroma . Arch Surg 95:934-936, 1967;.
23 +
Sabiston DC (ed): David-Christopher Textbook of Surgery , ed 11. Philadelphia, WB Saunders Inc, 1977;, pp 739-790.
24 +
Engelman K, Horwitz D, Jequiet E, et al:  Biochemical and pharmacologic effects of alpha-methyltyrosine in man . J Clin Invest 47:577-594, 1968;.

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