In Reply.—I thank Dr Perrin for correcting my statistics, which were incorrectly calculated on the basis of his total 54-patient group rather than on the actual number of treated patients. His new statistic for a two-month attack rate (4.6%) is even closer to my 5.6% rate and further emphasizes the improvement of 72% to 85% that occurred in both studies.
In the article, I stated that most parents will give a decongestant to their child if he or she has an upper respiratory infection, unless specifically instructed not to do so. Such is the power of television. Although not actually verified, the majority of the children who received sulfisoxazole probably also received a proprietary decongestant from their parents, tending to make the groups even more similar.
The difference in the rates of upper respiratory infection is reported as it happened. During the two-month period after otitis, all such infections